N-<2-(N',N'-diethylamino)ethyl>-5-<(4,5-diphenyl-1H-imidazol-2-yl)thio>pentanamide

Base Information

Chemical Name:N-<2-(N',N'-diethylamino)ethyl>-5-<(4,5-diphenyl-1H-imidazol-2-yl)thio>pentanamide
CAS No.:162687-82-3
Molecular Formula:C₂₆H₃₄N₄OS
Molecular Weight:450.648
Hs Code.:

Synonyms:N-<2-(N',N'-diethylamino)ethyl>-5-<(4,5-diphenyl-1H-imidazol-2-yl)thio>pentanamide

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Chemical Property of N-<2-(N',N'-diethylamino)ethyl>-5-<(4,5-diphenyl-1H-imidazol-2-yl)thio>pentanamide

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Technology Process of N-<2-(N',N'-diethylamino)ethyl>-5-<(4,5-diphenyl-1H-imidazol-2-yl)thio>pentanamide

There total 4 articles about N-<2-(N',N'-diethylamino)ethyl>-5-<(4,5-diphenyl-1H-imidazol-2-yl)thio>pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 119-53-9,579-44-2
2-hydroxy-2-phenylacetophenone

: 162687-82-3
N-<2-(N',N'-diethylamino)ethyl>-5-<(4,5-diphenyl-1H-imidazol-2-yl)thio>pentanamide

Guidance literature:: Multi-step reaction with 4 steps

1: dimethylformamide; various solvent(s) / 160 °C

2: K₂CO₃, tetra-n-butylammonium iodide / tetrahydrofuran / 2 h / Heating

3: NaOH

4: 1.) 1-hydroxybenzotriazole hydrate, 2.) dicyclohexylcarbodiimide / 1.) DMF, RT, 20 min, 2.) DMF, RT, 48 h

With sodium hydroxide; tetra-(n-butyl)ammonium iodide; potassium carbonate; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00007a004

Reference yield:

: 2349-58-8
4,5-diphenyl-1H-imidazole-2-thiol

: 162687-82-3
N-<2-(N',N'-diethylamino)ethyl>-5-<(4,5-diphenyl-1H-imidazol-2-yl)thio>pentanamide

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃, tetra-n-butylammonium iodide / tetrahydrofuran / 2 h / Heating

2: NaOH

3: 1.) 1-hydroxybenzotriazole hydrate, 2.) dicyclohexylcarbodiimide / 1.) DMF, RT, 20 min, 2.) DMF, RT, 48 h

With sodium hydroxide; tetra-(n-butyl)ammonium iodide; potassium carbonate; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran;
DOI:10.1021/jm00007a004

Reference yield:

: 130804-17-0
5-(4,5-diphenyl-1H-imidazol-2-ylthio)pentanoic acid ethyl ester

: 162687-82-3
N-<2-(N',N'-diethylamino)ethyl>-5-<(4,5-diphenyl-1H-imidazol-2-yl)thio>pentanamide

Guidance literature:: Multi-step reaction with 2 steps

1: NaOH

2: 1.) 1-hydroxybenzotriazole hydrate, 2.) dicyclohexylcarbodiimide / 1.) DMF, RT, 20 min, 2.) DMF, RT, 48 h

With sodium hydroxide; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide;
DOI:10.1021/jm00007a004