(1S,3S,3aS,4S,5R,7aS)-3-Benzenesulfonyl-1-hydroxymethyl-5-isopropyl-7a-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene-4-carboxylic acid methyl ester

Base Information

Chemical Name:(1S,3S,3aS,4S,5R,7aS)-3-Benzenesulfonyl-1-hydroxymethyl-5-isopropyl-7a-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene-4-carboxylic acid methyl ester
CAS No.:131250-70-9
Molecular Formula:C₂₂H₃₀O₅S
Molecular Weight:406.543
Hs Code.:

(1S,3S,3aS,4S,5R,7aS)-3-Benzenesulfonyl-1-hydroxymethyl-5-isopropyl-7a-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene-4-carboxylic acid methyl ester

Synonyms:(1S,3S,3aS,4S,5R,7aS)-3-Benzenesulfonyl-1-hydroxymethyl-5-isopropyl-7a-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene-4-carboxylic acid methyl ester

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Chemical Property of (1S,3S,3aS,4S,5R,7aS)-3-Benzenesulfonyl-1-hydroxymethyl-5-isopropyl-7a-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene-4-carboxylic acid methyl ester

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Technology Process of (1S,3S,3aS,4S,5R,7aS)-3-Benzenesulfonyl-1-hydroxymethyl-5-isopropyl-7a-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene-4-carboxylic acid methyl ester

There total 13 articles about (1S,3S,3aS,4S,5R,7aS)-3-Benzenesulfonyl-1-hydroxymethyl-5-isopropyl-7a-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 131250-71-0
(1S,3S,3aS,4S,5R,7aS)-3-Benzenesulfonyl-1-formyl-5-isopropyl-7a-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene-4-carboxylic acid methyl ester

: 131250-70-9
(1S,3S,3aS,4S,5R,7aS)-3-Benzenesulfonyl-1-hydroxymethyl-5-isopropyl-7a-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene-4-carboxylic acid methyl ester

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; methanol;
DOI:10.1021/ja00002a043

Reference yield:

: 131250-68-5
((3S,3aS,4S,5R,7aR)-3-Benzenesulfonyl-5-isopropyl-7a-methyl-1-methylene-2,3,3a,4,5,7a-hexahydro-1H-inden-4-yl)-methanol

: 131250-70-9
(1R,3S,3aS,4S,5R,7aS)-3-Benzenesulfonyl-1-hydroxymethyl-5-isopropyl-7a-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Jones reagent

2: diethyl ether

3: 1.) (thexyl)BH₂*S(CH₃)2, 2.) NaOH, H₂O₂ / 1.) CH₂Cl₂, 10 deg C

With sodium hydroxide; jones reagent; thexylborane-dimethylsulfide; dihydrogen peroxide; In diethyl ether;
DOI:10.1021/ja00002a043

Reference yield:

: 131250-68-5
((3S,3aS,4S,5R,7aR)-3-Benzenesulfonyl-5-isopropyl-7a-methyl-1-methylene-2,3,3a,4,5,7a-hexahydro-1H-inden-4-yl)-methanol

: 131250-70-9
(1S,3S,3aS,4S,5R,7aS)-3-Benzenesulfonyl-1-hydroxymethyl-5-isopropyl-7a-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: Jones reagent

2: diethyl ether

3: 1.) (thexyl)BH₂*S(CH₃)2, 2.) NaOH, H₂O₂ / 1.) CH₂Cl₂, 10 deg C

4: 95 percent / (COCl)2, DMSO, (C₂H₅)3N / CH₂Cl₂

5: 100 percent / DBU / benzene

6: 99 percent / NaBH₄ / methanol; tetrahydrofuran

With sodium hydroxide; sodium tetrahydroborate; jones reagent; oxalyl dichloride; thexylborane-dimethylsulfide; dihydrogen peroxide; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; benzene;
DOI:10.1021/ja00002a043