((3S,3aS,4S,5R,7aR)-3-Benzenesulfonyl-5-isopropyl-7a-methyl-1-methylene-2,3,3a,4,5,7a-hexahydro-1H-inden-4-yl)-methanol

Base Information

Chemical Name:((3S,3aS,4S,5R,7aR)-3-Benzenesulfonyl-5-isopropyl-7a-methyl-1-methylene-2,3,3a,4,5,7a-hexahydro-1H-inden-4-yl)-methanol
CAS No.:131250-68-5
Molecular Formula:C₂₁H₂₈O₃S
Molecular Weight:360.518
Hs Code.:

Synonyms:((3S,3aS,4S,5R,7aR)-3-Benzenesulfonyl-5-isopropyl-7a-methyl-1-methylene-2,3,3a,4,5,7a-hexahydro-1H-inden-4-yl)-methanol

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Chemical Property of ((3S,3aS,4S,5R,7aR)-3-Benzenesulfonyl-5-isopropyl-7a-methyl-1-methylene-2,3,3a,4,5,7a-hexahydro-1H-inden-4-yl)-methanol

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Technology Process of ((3S,3aS,4S,5R,7aR)-3-Benzenesulfonyl-5-isopropyl-7a-methyl-1-methylene-2,3,3a,4,5,7a-hexahydro-1H-inden-4-yl)-methanol

There total 2 articles about ((3S,3aS,4S,5R,7aR)-3-Benzenesulfonyl-5-isopropyl-7a-methyl-1-methylene-2,3,3a,4,5,7a-hexahydro-1H-inden-4-yl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 131250-66-3
(4S,4aS,8S,8aS)-4-Benzenesulfonyl-8-isopropyl-5-methyl-4-prop-2-ynyl-1,4,4a,7,8,8a-hexahydro-isochromen-3-one

: 131250-68-5
((3S,3aS,4S,5R,7aR)-3-Benzenesulfonyl-5-isopropyl-7a-methyl-1-methylene-2,3,3a,4,5,7a-hexahydro-1H-inden-4-yl)-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / (dba)3Pd₂*CHCl₃, triphenylphosphine, acetic acid / benzene / 50 - 55 °C

2: 1.) KOH, 2.) HCl / 1.) ethanol, reflux, 2.) water

With hydrogenchloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium hydroxide; acetic acid; triphenylphosphine; In benzene;
DOI:10.1021/ja00002a043

Reference yield:

: 131250-67-4
(2aS,5aS,6R,8aR,8bS)-2a-Benzenesulfonyl-6-isopropyl-8a-methyl-1-methylene-1,2,2a,5,5a,6,8a,8b-octahydro-4-oxa-acenaphthylen-3-one

: 131250-68-5
((3S,3aS,4S,5R,7aR)-3-Benzenesulfonyl-5-isopropyl-7a-methyl-1-methylene-2,3,3a,4,5,7a-hexahydro-1H-inden-4-yl)-methanol

Guidance literature:: With hydrogenchloride; potassium hydroxide; Yield given. Multistep reaction; 1.) ethanol, reflux, 2.) water;
DOI:10.1021/ja00002a043

Reference yield:

: 131250-68-5
((3S,3aS,4S,5R,7aR)-3-Benzenesulfonyl-5-isopropyl-7a-methyl-1-methylene-2,3,3a,4,5,7a-hexahydro-1H-inden-4-yl)-methanol

: 131250-70-9
(1R,3S,3aS,4S,5R,7aS)-3-Benzenesulfonyl-1-hydroxymethyl-5-isopropyl-7a-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Jones reagent

2: diethyl ether

3: 1.) (thexyl)BH₂*S(CH₃)2, 2.) NaOH, H₂O₂ / 1.) CH₂Cl₂, 10 deg C

With sodium hydroxide; jones reagent; thexylborane-dimethylsulfide; dihydrogen peroxide; In diethyl ether;
DOI:10.1021/ja00002a043