(2aS,5aS,6R,8aR,8bS)-2a-Benzenesulfonyl-6-isopropyl-8a-methyl-1-methylene-1,2,2a,5,5a,6,8a,8b-octahydro-4-oxa-acenaphthylen-3-one

Base Information

Chemical Name:(2aS,5aS,6R,8aR,8bS)-2a-Benzenesulfonyl-6-isopropyl-8a-methyl-1-methylene-1,2,2a,5,5a,6,8a,8b-octahydro-4-oxa-acenaphthylen-3-one
CAS No.:131250-67-4
Molecular Formula:C₂₂H₂₆O₄S
Molecular Weight:386.512
Hs Code.:

Synonyms:(2aS,5aS,6R,8aR,8bS)-2a-Benzenesulfonyl-6-isopropyl-8a-methyl-1-methylene-1,2,2a,5,5a,6,8a,8b-octahydro-4-oxa-acenaphthylen-3-one

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Chemical Property of (2aS,5aS,6R,8aR,8bS)-2a-Benzenesulfonyl-6-isopropyl-8a-methyl-1-methylene-1,2,2a,5,5a,6,8a,8b-octahydro-4-oxa-acenaphthylen-3-one

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Technology Process of (2aS,5aS,6R,8aR,8bS)-2a-Benzenesulfonyl-6-isopropyl-8a-methyl-1-methylene-1,2,2a,5,5a,6,8a,8b-octahydro-4-oxa-acenaphthylen-3-one

There total 1 articles about (2aS,5aS,6R,8aR,8bS)-2a-Benzenesulfonyl-6-isopropyl-8a-methyl-1-methylene-1,2,2a,5,5a,6,8a,8b-octahydro-4-oxa-acenaphthylen-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 131250-66-3
(4S,4aS,8S,8aS)-4-Benzenesulfonyl-8-isopropyl-5-methyl-4-prop-2-ynyl-1,4,4a,7,8,8a-hexahydro-isochromen-3-one

: 131250-67-4
(2aS,5aS,6R,8aR,8bS)-2a-Benzenesulfonyl-6-isopropyl-8a-methyl-1-methylene-1,2,2a,5,5a,6,8a,8b-octahydro-4-oxa-acenaphthylen-3-one

Guidance literature:: With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; acetic acid; triphenylphosphine; In benzene; at 50 - 55 ℃;
DOI:10.1021/ja00002a043

Reference yield:

: 131250-67-4
(2aS,5aS,6R,8aR,8bS)-2a-Benzenesulfonyl-6-isopropyl-8a-methyl-1-methylene-1,2,2a,5,5a,6,8a,8b-octahydro-4-oxa-acenaphthylen-3-one

: 131250-69-6
(3S,3aS,4S,5R,7aR)-3-Benzenesulfonyl-5-isopropyl-7a-methyl-1-methylene-2,3,3a,4,5,7a-hexahydro-1H-indene-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) KOH, 2.) HCl / 1.) ethanol, reflux, 2.) water

2: Jones reagent

3: diethyl ether

With hydrogenchloride; potassium hydroxide; jones reagent; In diethyl ether;
DOI:10.1021/ja00002a043

Reference yield:

: 131250-67-4
(2aS,5aS,6R,8aR,8bS)-2a-Benzenesulfonyl-6-isopropyl-8a-methyl-1-methylene-1,2,2a,5,5a,6,8a,8b-octahydro-4-oxa-acenaphthylen-3-one

: 131250-70-9
(1R,3S,3aS,4S,5R,7aS)-3-Benzenesulfonyl-1-hydroxymethyl-5-isopropyl-7a-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) KOH, 2.) HCl / 1.) ethanol, reflux, 2.) water

2: Jones reagent

3: diethyl ether

4: 1.) (thexyl)BH₂*S(CH₃)2, 2.) NaOH, H₂O₂ / 1.) CH₂Cl₂, 10 deg C

With hydrogenchloride; potassium hydroxide; sodium hydroxide; jones reagent; thexylborane-dimethylsulfide; dihydrogen peroxide; In diethyl ether;
DOI:10.1021/ja00002a043