1-(4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl) urea

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Chemical Name:1-(4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl) urea
CAS No.:1571073-75-0
Molecular Formula:C₄₂H₄₉N₇O₇Si
Molecular Weight:791.979
Hs Code.:

1-(4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl) urea

Synonyms:1-(4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl) urea

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Chemical Property of 1-(4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl) urea

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Technology Process of 1-(4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl) urea

There total 5 articles about 1-(4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl) urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72593-77-2,92450-98-1
3,6,9-trioxadecyl bromide

: 1571073-75-0
1-(4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl) urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium iodide; potassium carbonate / acetone / 16 h / Reflux

2.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 8 h / 65 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4.1: triethylamine; diphenyl phosphoryl azide / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C

4.2: 1 h / 100 °C

With diphenyl phosphoryl azide; potassium carbonate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; sodium iodide; In dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 813449-46-6
1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazole-5-carboxylic acid

: 1571074-05-9
4-((4-aminonaphthalen-1-yl)oxy)-N-(3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)-ethoxy)phenyl)pyrimidin-2-amine

: 1571073-75-0
1-(4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl) urea

Guidance literature:: 1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazole-5-carboxylic acid; With diphenyl phosphoryl azide; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1.5h;

4-((4-aminonaphthalen-1-yl)oxy)-N-(3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)-ethoxy)phenyl)pyrimidin-2-amine; In N,N-dimethyl-formamide; at 100 ℃; for 1h;

Reference yield:

: 1571074-03-7
3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)aniline

: 1571073-75-0
1-(4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl) urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 8 h / 65 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.1: triethylamine; diphenyl phosphoryl azide / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C

3.2: 1 h / 100 °C

With diphenyl phosphoryl azide; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;