tert-butyl (4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)carbamate

Base Information

Chemical Name:tert-butyl (4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)carbamate
CAS No.:1571074-04-8
Molecular Formula:C₃₃H₄₀N₄O₈
Molecular Weight:620.703
Hs Code.:

Synonyms:tert-butyl (4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)carbamate

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Chemical Property of tert-butyl (4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)carbamate

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Technology Process of tert-butyl (4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)carbamate

There total 6 articles about tert-butyl (4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72593-77-2,92450-98-1
3,6,9-trioxadecyl bromide

: 1571074-04-8
tert-butyl (4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium iodide; potassium carbonate / acetone / 16 h / Reflux

2: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 8 h / 65 °C

With potassium carbonate; toluene-4-sulfonic acid; sodium iodide; In N,N-dimethyl-formamide; acetone;

Reference yield:

: 1229607-86-6
tert-butyl (4-((2-chloropyrimidin-4-yl)oxy)-naphthalen-1-yl)carbamate

: 1571074-03-7
3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)aniline

: 1571074-04-8
tert-butyl (4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)carbamate

Guidance literature:: With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; at 65 ℃; for 8h;

Reference yield:

: 16618-67-0
3-bromo-5-nitroanisole

: 1571074-04-8
tert-butyl (4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)amino) pyrimidin-4-yl)oxy)naphthalen-1-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium hydroxide; tert-butyl XPhos / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

2: potassium carbonate / acetone / Reflux

3: ammonium chloride; iron / water; ethanol / 3 h / 80 °C

4: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 14 h / 55 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; iron; potassium carbonate; ammonium chloride; toluene-4-sulfonic acid; potassium hydroxide; tert-butyl XPhos; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; acetone;