3-[2-[(4-chlorophenyl)sulphonylamino]ethyl]-5-(4-methoxybenzoyl)benzenepropanoic acid

Base Information

Chemical Name:3-[2-[(4-chlorophenyl)sulphonylamino]ethyl]-5-(4-methoxybenzoyl)benzenepropanoic acid
CAS No.:161777-88-4
Molecular Formula:C₂₅H₂₄ClNO₆S
Molecular Weight:501.988
Hs Code.:

Synonyms:3-[2-[(4-chlorophenyl)sulphonylamino]ethyl]-5-(4-methoxybenzoyl)benzenepropanoic acid

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Chemical Property of 3-[2-[(4-chlorophenyl)sulphonylamino]ethyl]-5-(4-methoxybenzoyl)benzenepropanoic acid

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Technology Process of 3-[2-[(4-chlorophenyl)sulphonylamino]ethyl]-5-(4-methoxybenzoyl)benzenepropanoic acid

There total 10 articles about 3-[2-[(4-chlorophenyl)sulphonylamino]ethyl]-5-(4-methoxybenzoyl)benzenepropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 67-56-1
methanol

: 161777-86-2
3-[2-[(4-chlorophenyl)sulphonylamino]ethyl]-5-(4-fluorobenzoyl)benzenepropanoic acid

: 161777-88-4
3-[2-[(4-chlorophenyl)sulphonylamino]ethyl]-5-(4-methoxybenzoyl)benzenepropanoic acid

Guidance literature:: With potassium carbonate; Heating;
DOI:10.1016/S0960-894X(98)00242-X

Reference yield:

: 161777-86-2
3-[2-[(4-chlorophenyl)sulphonylamino]ethyl]-5-(4-fluorobenzoyl)benzenepropanoic acid

: 161777-88-4
3-[2-[(4-chlorophenyl)sulphonylamino]ethyl]-5-(4-methoxybenzoyl)benzenepropanoic acid

Guidance literature:: With potassium carbonate; In methanol; water;

Reference yield:

: 626-39-1
1,3,5-trisbromobenzene

: 161777-88-4
3-[2-[(4-chlorophenyl)sulphonylamino]ethyl]-5-(4-methoxybenzoyl)benzenepropanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) n-BuLi / 1.) Et₂O, 2.) Et₂O

2: 89 percent / Pd(OAc)2, P(o-Tol)3, Et₃N / acetonitrile / Heating

3: 99 percent / HCO₂NH₄ / Pd/C / ethanol; tetrahydrofuran

4: 95 percent / (COCl₂)2, DMSO, Et₃N / CH₂Cl₂

5: 50 percent / aq. NaOH / ethanol

6: 1.) (COCl)2, 2.) NH₄OH / 1.) CH₂Cl₂

7: 1.) NaOCl, aq. NaOH / 1.) dioxan, reflux

8: 89 percent / K₂CO₃ / Heating

With palladium diacetate; ammonium hydroxide; sodium hydroxide; sodium hypochlorite; n-butyllithium; oxalyl dichloride; (COCl₂)2; ammonium formate; potassium carbonate; dimethyl sulfoxide; triethylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1016/S0960-894X(98)00242-X