Technology Process of 5-methoxy-1,3-phenylene dipivalate
There total 1 articles about 5-methoxy-1,3-phenylene dipivalate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dmap; triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 0.333333h;
DOI:10.1021/ol4011757
- Guidance literature:
-
With
water; sodium hydroxide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 36h;
DOI:10.1021/ol4011757
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydroxide; water / N,N-dimethyl-formamide / 36 h / 20 °C
2.1: dmap; triethylamine / dichloromethane / 0.08 h / 0 - 20 °C
3.1: potassium phosphate; ethanol / 10 h / 70 °C
4.1: sodium hydride / 1,2-dimethoxyethane / 0.17 h / 0 °C / Schlenk technique
4.2: 1 h / 20 °C / Schlenk technique
5.1: potassium phosphate; palladium diacetate; XPhos / tert-butyl alcohol / 12 h / 90 °C / Inert atmosphere; Schlenk technique
6.1: bis(tricyclohexylphosphine)nickel(II) dichloride; tricyclohexylphosphine; potassium carbonate / 1,4-dioxane / 24 h / 120 °C / Inert atmosphere; Schlenk technique
7.1: bis(tricyclohexylphosphine)nickel(II) dichloride / toluene / 24 h / 130 °C / Inert atmosphere; Schlenk technique
With
dmap; potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride; ethanol; water; palladium diacetate; sodium hydride; potassium carbonate; triethylamine; sodium hydroxide; XPhos; tricyclohexylphosphine;
In
1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;
5.1: |Suzuki-Miyaura Coupling / 6.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/ol4011757
