N-(2-azidoethyl)-4-(4-(bis(2-chloroethyl)amino)phenyl)butanamide

Base Information

• Chemical Name: N-(2-azidoethyl)-4-(4-(bis(2-chloroethyl)amino)phenyl)butanamide
• CAS No.: 1595051-08-3
• Molecular Formula: C₁₆H₂₃Cl₂N₅O
• Molecular Weight: 372.298
• Mol file: 1595051-08-3.mol

Synonyms:N-(2-azidoethyl)-4-(4-(bis(2-chloroethyl)amino)phenyl)butanamide

Chemical Property of N-(2-azidoethyl)-4-(4-(bis(2-chloroethyl)amino)phenyl)butanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-azidoethyl)-4-(4-(bis(2-chloroethyl)amino)phenyl)butanamide

There total 2 articles about N-(2-azidoethyl)-4-(4-(bis(2-chloroethyl)amino)phenyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chlorambucil chloride (17981-81-6) + 2-azidoethan-1-amine monohydrochloride → N-(2-azidoethyl)-4-(4-(bis(2-chloroethyl)amino)phenyl)butanamide (1595051-08-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1021/ja5014344

Reference yield:

chlorambucil (305-03-3) → N-(2-azidoethyl)-4-(4-(bis(2-chloroethyl)amino)phenyl)butanamide (1595051-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 0 °C / Inert atmosphere

2: triethylamine / dichloromethane / 1 h / 0 - 20 °C

With thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1021/ja5014344

Reference yield: 71.0%

C42H45N7O9 (1417638-67-5) + N-(2-azidoethyl)-4-(4-(bis(2-chloroethyl)amino)phenyl)butanamide (1595051-08-3) → C58H68Cl2N12O10

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 0 ℃; Inert atmosphere;

DOI:10.1021/ja5014344

upstream raw materials:

chlorambucil chloride

chlorambucil

Downstream raw materials:

C₄₈H₅₂Cl₂N₁₂O₆