5-(4-nitrophenyl)sulfonyl-4,6-dihydropyrrolo[3,4-d]thiazole

Base Information

• Chemical Name: 5-(4-nitrophenyl)sulfonyl-4,6-dihydropyrrolo[3,4-d]thiazole
• CAS No.: 1393686-90-2
• Molecular Formula: C₁₁H₉N₃O₄S₂
• Molecular Weight: 311.342
• Mol file: 1393686-90-2.mol

Synonyms:5-(4-nitrophenyl)sulfonyl-4,6-dihydropyrrolo[3,4-d]thiazole

Chemical Property of 5-(4-nitrophenyl)sulfonyl-4,6-dihydropyrrolo[3,4-d]thiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-nitrophenyl)sulfonyl-4,6-dihydropyrrolo[3,4-d]thiazole

There total 2 articles about 5-(4-nitrophenyl)sulfonyl-4,6-dihydropyrrolo[3,4-d]thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

p-nitrobenzenesulfonamide (6325-93-5) + [5-(hydroxymethyl)thiazol-4-yl]methanol (1393686-89-9) → 5-(4-nitrophenyl)sulfonyl-4,6-dihydropyrrolo[3,4-d]thiazole (1393686-90-2)

Guidance literature:

With cyanomethylenetributyl-phosphorane; In tetrahydrofuran; toluene; at 80 ℃; for 2.5h; Inert atmosphere;

DOI:10.3987/COM-12-12481

Reference yield:

diethyl thiazole-4,5-dicarboxylate (18940-72-2) → 5-(4-nitrophenyl)sulfonyl-4,6-dihydropyrrolo[3,4-d]thiazole (1393686-90-2)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium borohydride / tetrahydrofuran; methanol / 1 h / 20 °C

2: cyanomethylenetributyl-phosphorane / tetrahydrofuran; toluene / 2.5 h / 80 °C / Inert atmosphere

With lithium borohydride; cyanomethylenetributyl-phosphorane; In tetrahydrofuran; methanol; toluene; 2: Mitsunobu reaction;

DOI:10.3987/COM-12-12481

Reference yield: 73.0%

5-(4-nitrophenyl)sulfonyl-4,6-dihydropyrrolo[3,4-d]thiazole (1393686-90-2) → 5,6-dihydro-4H-pyrrolo[3,4-d]thiazole

Guidance literature:

With caesium carbonate; In tetrahydrofuran; methanol; at 20 ℃; for 18h;

DOI:10.3987/COM-12-12481

upstream raw materials:

p-nitrobenzenesulfonamide

[5-(hydroxymethyl)thiazol-4-yl]methanol

diethyl thiazole-4,5-dicarboxylate