ethyl 2-((R)-1-((S)-2-(tert-butyldimethylsilyloxy)-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)acetate

Base Information

• Chemical Name: ethyl 2-((R)-1-((S)-2-(tert-butyldimethylsilyloxy)-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)acetate
• CAS No.: 1265323-61-2
• Molecular Formula: C₃₅H₄₃F₃N₄O₅Si
• Molecular Weight: 684.831
• Mol file: 1265323-61-2.mol

Synonyms:ethyl 2-((R)-1-((S)-2-(tert-butyldimethylsilyloxy)-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)acetate

Chemical Property of ethyl 2-((R)-1-((S)-2-(tert-butyldimethylsilyloxy)-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-((R)-1-((S)-2-(tert-butyldimethylsilyloxy)-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)acetate

There total 15 articles about ethyl 2-((R)-1-((S)-2-(tert-butyldimethylsilyloxy)-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

syn-benzaldehyde oxime (932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2) → ethyl 2-((R)-1-((S)-2-(tert-butyldimethylsilyloxy)-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)acetate (1265323-61-2)

Guidance literature:

Multi-step reaction with 5 steps

1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2: 1,1-dichloroethane / 20 - 70 °C

3: 2,2,6,6-tetramethyl-piperidine-N-oxyl; disodium hydrogenphosphate; sodium chlorite; sodium dihydrogenphosphate / acetonitrile; water / 20 - 35 °C

4: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 - 25 °C

5: N-ethyl-N,N-diisopropylamine / acetonitrile / 120 h / 25 °C

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium chlorite; disodium hydrogenphosphate; sodium dihydrogenphosphate; N-chloro-succinimide; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In 1,1-dichloroethane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

3-phenyl-4-(trifluoromethyl)isoxazole-5-carbonyl chloride (1265324-15-9) + ethyl 2-((R)-1-((S)-2-(tert-butyldimethylsilyloxy)-2-(4-((Z)-N'-hydroxycarbamimidoyl)phenyl)ethyl)piperidin-3-yl)acetate (1265750-10-4) → ethyl 2-((R)-1-((S)-2-(tert-butyldimethylsilyloxy)-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)acetate (1265323-61-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 25 ℃; for 120h;

Reference yield:

phenylhydroxamoyl chloride (934-16-7) → ethyl 2-((R)-1-((S)-2-(tert-butyldimethylsilyloxy)-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)acetate (1265323-61-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1,1-dichloroethane / 20 - 70 °C

2: 2,2,6,6-tetramethyl-piperidine-N-oxyl; disodium hydrogenphosphate; sodium chlorite; sodium dihydrogenphosphate / acetonitrile; water / 20 - 35 °C

3: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 - 25 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 120 h / 25 °C

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium chlorite; disodium hydrogenphosphate; sodium dihydrogenphosphate; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In 1,1-dichloroethane; dichloromethane; water; acetonitrile;

upstream raw materials:

4-Cyanophenacyl bromide

phenylhydroxamoyl chloride

t-butyldimethylsiyl triflate

syn-benzaldehyde oxime