(S)-2-phthalimidopropyl benzyl ether

Base Information

• Chemical Name: (S)-2-phthalimidopropyl benzyl ether
• CAS No.: 83053-83-2
• Molecular Formula: C₁₈H₁₇NO₃
• Molecular Weight: 295.338
• Mol file: 83053-83-2.mol

Synonyms:(S)-2-phthalimidopropyl benzyl ether

Chemical Property of (S)-2-phthalimidopropyl benzyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-phthalimidopropyl benzyl ether

There total 2 articles about (S)-2-phthalimidopropyl benzyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-ethoxycarbonylphthalimide (22509-74-6) → (S)-2-phthalimidopropyl benzyl ether (83053-83-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / tetrahydrofuran / Ambient temperature

2: 1.) potassium hydride, dibenzo-18-crown-6 / 1.) tetrahydrofuran, room temperature, 1 h, 2.) tetrahydrofuran, room temperature, 48 h

With dibenzo-18-crown-6; potassium hydride; In tetrahydrofuran;

DOI:10.1139/v82-254

Reference yield:

benzyl bromide (100-39-0) + 2-((2S)-1-hydroxypropan-2-yl)-1H-isoindole-1,3(2H)-dione (70058-19-4) → (S)-2-phthalimidopropyl benzyl ether (83053-83-2)

Guidance literature:

With dibenzo-18-crown-6; potassium hydride; Yield given. Multistep reaction; 1.) tetrahydrofuran, room temperature, 1 h, 2.) tetrahydrofuran, room temperature, 48 h;

DOI:10.1139/v82-254

Reference yield: 92.3%

(S)-2-phthalimidopropyl benzyl ether (83053-83-2) → (S)-1-(benzyloxy)-2-propylamine (83053-85-4)

Guidance literature:

With hydrazine; In ethanol; water; at 30 ℃; for 2h;

DOI:10.1139/v82-254

upstream raw materials:

benzyl bromide

2-((2S)-1-hydroxypropan-2-yl)-1H-isoindole-1,3(2H)-dione

N-ethoxycarbonylphthalimide

Downstream raw materials:

(S)-1-(benzyloxy)-2-propylamine

(S)-2-cyclohexylideneaminopropyl benzyl ether