di-tert-butyl (2R)-2-(((3S)-3-methyl-4-morpholinyl)carbonyl)-1,4-piperazinedicarboxylate

Base Information

Chemical Name:di-tert-butyl (2R)-2-(((3S)-3-methyl-4-morpholinyl)carbonyl)-1,4-piperazinedicarboxylate
CAS No.:1361218-82-7
Molecular Formula:C₂₀H₃₅N₃O₆
Molecular Weight:413.514
Hs Code.:

Synonyms:di-tert-butyl (2R)-2-(((3S)-3-methyl-4-morpholinyl)carbonyl)-1,4-piperazinedicarboxylate

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Chemical Property of di-tert-butyl (2R)-2-(((3S)-3-methyl-4-morpholinyl)carbonyl)-1,4-piperazinedicarboxylate

Chemical Property:

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Technology Process of di-tert-butyl (2R)-2-(((3S)-3-methyl-4-morpholinyl)carbonyl)-1,4-piperazinedicarboxylate

There total 1 articles about di-tert-butyl (2R)-2-(((3S)-3-methyl-4-morpholinyl)carbonyl)-1,4-piperazinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 350595-57-2
(S)-3-methylmorpholine

: 173774-48-6
(R)-piperazine-1,2,4-tricarboxylic acid 1,4-di-tert-butyl ester

: 1361218-82-7
di-tert-butyl (2R)-2-(((3S)-3-methyl-4-morpholinyl)carbonyl)-1,4-piperazinedicarboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In water; N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1021/jm4016735

Reference yield:

: 1361218-82-7
di-tert-butyl (2R)-2-(((3S)-3-methyl-4-morpholinyl)carbonyl)-1,4-piperazinedicarboxylate

: (2R)-1,1,1-trifluoro-2-(4-((2S)-2-(((3S)-3-methyl-4-morpholinyl)methyl)-4-(phenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: borane-THF / tetrahydrofuran / 16 h / 50 °C

1.2: 20 °C

2.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 6 h / 70 °C

3.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

4.1: sodium t-butanolate / ruphos; chloro(2-dicyclohexylphosphino-2',6'-di-i-propoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) methyl-t-butylether adduct / toluene / 12 h / 60 °C / sealed vessel

With hydrogenchloride; borane-THF; triethylamine; sodium t-butanolate; chloro(2-dicyclohexylphosphino-2',6'-di-i-propoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) methyl-t-butylether adduct; ruphos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate; toluene;

Reference yield:

: 1361218-82-7
di-tert-butyl (2R)-2-(((3S)-3-methyl-4-morpholinyl)carbonyl)-1,4-piperazinedicarboxylate

: 1361218-83-8
3,3,3-trifluoro-2-(4-((2S)-2-(((3S)-3-methyl-4-morpholinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-1,2-propanediol

Guidance literature:: Multi-step reaction with 4 steps

1.1: borane-THF / tetrahydrofuran / 16 h / 50 °C

1.2: 20 °C

2.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 6 h / 70 °C

3.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

4.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos / toluene / 1 h / 100 °C / sealed vial

With hydrogenchloride; borane-THF; triethylamine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate; toluene;