(S)-N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-((2-(hydroxymethyl)piperazin-1-yl)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide

Base Information

Chemical Name:(S)-N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-((2-(hydroxymethyl)piperazin-1-yl)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide
CAS No.:1070295-55-4
Molecular Formula:C₃₀H₃₅FN₄O₃
Molecular Weight:518.631
Hs Code.:

(S)-N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-((2-(hydroxymethyl)piperazin-1-yl)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide

Synonyms:(S)-N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-((2-(hydroxymethyl)piperazin-1-yl)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide

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Chemical Property of (S)-N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-((2-(hydroxymethyl)piperazin-1-yl)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide

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Technology Process of (S)-N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-((2-(hydroxymethyl)piperazin-1-yl)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide

There total 4 articles about (S)-N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-((2-(hydroxymethyl)piperazin-1-yl)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 314741-40-7
(3S)-3-(hydroxymethyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester

: 1070294-74-4
N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-formyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide

: 1070295-55-4
(S)-N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-((2-(hydroxymethyl)piperazin-1-yl)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide

Guidance literature:: (3S)-3-(hydroxymethyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-formyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide; With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 12h;

With acetic acid; In dichloromethane; for 12h;

With hydrogenchloride; ammonia; sodium cyanoborohydride; more than 3 stages;

Reference yield:

: 1070294-27-7
6-bromo-2-(2-cyclopropanemethyl)isoquinolin-1(2H)-one

: 1070295-55-4
(S)-N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-((2-(hydroxymethyl)piperazin-1-yl)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 0.17 h / 0 - 20 °C

1.2: 80 °C

1.3: 0.33 h / 0 °C

2.1: potassium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / N,N-dimethyl-formamide / 11 h / 60 °C

3.1: sodium tris(acetoxy)borohydride / dichloromethane / 12 h / 20 °C

3.2: 12 h

With sodium tris(acetoxy)borohydride; potassium carbonate; trichlorophosphate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1070294-29-9
6-bromo-2-cyclopropylmethyl-1-oxo-1,2-dihydroisoquinoline-4-carbaldehyde

: 1070295-55-4
(S)-N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-((2-(hydroxymethyl)piperazin-1-yl)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / N,N-dimethyl-formamide / 11 h / 60 °C

2.1: sodium tris(acetoxy)borohydride / dichloromethane / 12 h / 20 °C

2.2: 12 h

With sodium tris(acetoxy)borohydride; potassium carbonate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In dichloromethane; N,N-dimethyl-formamide;