(S)-4-N-Boc-2-(hydroxymethyl)piperazine

Base Information

• Chemical Name: (S)-4-N-Boc-2-(hydroxymethyl)piperazine
• CAS No.: 314741-40-7
• Molecular Formula: C10H20N2O3
• Molecular Weight: 216.28
• Hs Code.: 2933599090
• Mol file: 314741-40-7.mol

Synonyms:(S)-3-Hydroxymethylpiperazine-1-carboxylicacid tert-butyl ester;tert-Butyl (3S)-3-(hydroxymethyl)piperazine-1-carboxylate;

Chemical Property of (S)-4-N-Boc-2-(hydroxymethyl)piperazine

Chemical Property:

• Vapor Pressure: 2.15E-05mmHg at 25°C
• Refractive Index: 1.477
• Boiling Point: 322.9 °C at 760 mmHg
• PKA: 14.97±0.10(Predicted)
• Flash Point: 149.1 °C
• PSA: 61.80000
• Density: 1.085 g/cm³
• LogP: 0.45430
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

(S)-1-Boc-3-hydroxymethyl-piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (S)-4-N-Boc-2-(hydroxymethyl)piperazine is a useful research chemical.

Technology Process of (S)-4-N-Boc-2-(hydroxymethyl)piperazine

There total 9 articles about (S)-4-N-Boc-2-(hydroxymethyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

O1-tert-butyl O3-methyl (3S)-piperazine-1,3-dicarboxylate (314741-39-4) → (3S)-3-(hydroxymethyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester (314741-40-7)

Guidance literature:

With sodium hydroxide; sodium sulfate; In tetrahydrofuran;

Reference yield:

(S)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid (848482-93-9) → (3S)-3-(hydroxymethyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester (314741-40-7)

Guidance literature:

(S)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid; With borane-THF; In tetrahydrofuran; at 90 ℃; for 4h; Heating / reflux;

With methanol; In tetrahydrofuran; at 0 ℃;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (S)-2-hydroxymethylpiperazine (126872-94-4) → (3S)-3-(hydroxymethyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester (314741-40-7)

Guidance literature:

In methanol; at -15 - 0 ℃; for 2h;

upstream raw materials:

tert-butyl (8aS)-3-oxotetrahydro-1,3-oxazolo[3,4-a]pyrazine-7(1H)-carboxylate

(2S)-1,4-bis(tert-butoxycarbonyl)piperazine-2-carboxylic acid

1,4-di-tert-butyl 2-methyl (2S)-piperazine-1,2,4-tricarboxylate

di-tert-butyl (2S)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate

Downstream raw materials:

(S)-tert-butyl 4-benzyl-3-(hydroxymethyl)piperazine-1-carboxylate

(S)-(4-methyl-piperazin-2-yl)-methanol

1-allyl 4-tert-butyl (S)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate

C₃₇H₄₆FN₃O₁₀

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