N-(3,5-bis-trifluoromethyl-benzyl)-2-(4-fluoro-phenyl)-4-oxo-butyramide

Base Information

Chemical Name:N-(3,5-bis-trifluoromethyl-benzyl)-2-(4-fluoro-phenyl)-4-oxo-butyramide
CAS No.:903512-72-1
Molecular Formula:C₁₉H₁₄F₇NO₂
Molecular Weight:421.314
Hs Code.:

<i>N</i>-(3,5-bis-trifluoromethyl-benzyl)-2-(4-fluoro-phenyl)-4-oxo-butyramide

Synonyms:N-(3,5-bis-trifluoromethyl-benzyl)-2-(4-fluoro-phenyl)-4-oxo-butyramide

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Chemical Property of N-(3,5-bis-trifluoromethyl-benzyl)-2-(4-fluoro-phenyl)-4-oxo-butyramide

Chemical Property:

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Technology Process of N-(3,5-bis-trifluoromethyl-benzyl)-2-(4-fluoro-phenyl)-4-oxo-butyramide

There total 4 articles about N-(3,5-bis-trifluoromethyl-benzyl)-2-(4-fluoro-phenyl)-4-oxo-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 691875-76-0
(S)-2-(4-Fluoro-phenyl)-pent-4-enoic acid 3,5-bis-trifluoromethyl-benzylamide

: 903512-72-1
N-(3,5-bis-trifluoromethyl-benzyl)-2-(4-fluoro-phenyl)-4-oxo-butyramide

Guidance literature:: (S)-2-(4-Fluoro-phenyl)-pent-4-enoic acid 3,5-bis-trifluoromethyl-benzylamide; With ozone; In acetone; at -78 ℃; for 0.25h;

With dimethylsulfide; In acetone; at -78 - 20 ℃;
DOI:10.1021/jm060439n

Reference yield:

: 51230-93-4
2-(4-fluorophenyl)pent-4-enoic acid

: 903512-72-1
N-(3,5-bis-trifluoromethyl-benzyl)-2-(4-fluoro-phenyl)-4-oxo-butyramide

Guidance literature:: Multi-step reaction with 3 steps

1.1: (S)-(-)-α-methylbenzylamine / ethyl acetate

2.1: 9.41 g / EDC; HOBt / CH₂Cl₂ / 20 °C

3.1: O₃ / acetone / 0.25 h / -78 °C

3.2: dimethylsulfide / acetone / -78 - 20 °C

With (S)-1-phenyl-ethylamine; benzotriazol-1-ol; ozone; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; ethyl acetate; acetone;
DOI:10.1021/jm060439n

Reference yield:

: 494802-92-5
(S)-2-(4-fluorophenyl)-4-pentenoic acid

: 903512-72-1
N-(3,5-bis-trifluoromethyl-benzyl)-2-(4-fluoro-phenyl)-4-oxo-butyramide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 9.41 g / EDC; HOBt / CH₂Cl₂ / 20 °C

2.1: O₃ / acetone / 0.25 h / -78 °C

2.2: dimethylsulfide / acetone / -78 - 20 °C

With benzotriazol-1-ol; ozone; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; acetone;
DOI:10.1021/jm060439n