C₄₈H₅₀ClNO₂₃

Base Information

• Chemical Name: C₄₈H₅₀ClNO₂₃
• CAS No.: 1054662-94-0
• Molecular Formula: C₄₈H₅₀ClNO₂₃
• Molecular Weight: 1044.37
• Mol file: 1054662-94-0.mol

Synonyms:C₄₈H₅₀ClNO₂₃

Chemical Property of C₄₈H₅₀ClNO₂₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of C₄₈H₅₀ClNO₂₃

There total 5 articles about C₄₈H₅₀ClNO₂₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

doxorubicin (23214-92-8) + (2S,3S,4S,5R,6S)-3,4,5-Triacetoxy-6-[4-chloro-2-(4-nitro-phenoxycarbonyloxymethyl)-phenoxy]-tetrahydro-pyran-2-carboxylic acid methyl ester (148580-11-4) → C48H50ClNO23 (1054662-94-0)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; for 2h; Ambient temperature;

DOI:10.1021/jm970589l

Reference yield:

5-chlorosalicyclaldehyde (635-93-8) → C48H50ClNO23 (1054662-94-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 55 percent / silver oxide / acetonitrile / 4 h / Ambient temperature

2: 90 percent / NaBH₄, silica gel HL₆₀ / CHCl₃; propan-2-ol / 0.75 h / 0 °C

3: 66 percent / Et₃N / CH₂Cl₂; acetonitrile / 1.5 h / 0 °C

4: 75 percent / Et₃N / dimethylformamide / 2 h / Ambient temperature

With sodium tetrahydroborate; silica gel; triethylamine; silver(l) oxide; In dichloromethane; chloroform; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

DOI:10.1021/jm970589l

Reference yield:

(2S,3S,4S,5R,6S)-3,4,5-Triacetoxy-6-(4-chloro-2-formyl-phenoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester (148580-09-0) → C48H50ClNO23 (1054662-94-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / NaBH₄, silica gel HL₆₀ / CHCl₃; propan-2-ol / 0.75 h / 0 °C

2: 66 percent / Et₃N / CH₂Cl₂; acetonitrile / 1.5 h / 0 °C

3: 75 percent / Et₃N / dimethylformamide / 2 h / Ambient temperature

With sodium tetrahydroborate; silica gel; triethylamine; In dichloromethane; chloroform; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

DOI:10.1021/jm970589l

upstream raw materials:

doxorubicin

(2S,3S,4S,5R,6S)-3,4,5-Triacetoxy-6-[4-chloro-2-(4-nitro-phenoxycarbonyloxymethyl)-phenoxy]-tetrahydro-pyran-2-carboxylic acid methyl ester

5-chlorosalicyclaldehyde

(2S,3S,4S,5R,6S)-3,4,5-Triacetoxy-6-(4-chloro-2-formyl-phenoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

Downstream raw materials:

C₄₂H₄₄ClNO₂₀