4-Chloro-1,3-Dimethyl-1H-Pyrazolo[3,4-B]Pyridine-5-Carboxamide

Base Information

Chemical Name:4-Chloro-1,3-Dimethyl-1H-Pyrazolo[3,4-B]Pyridine-5-Carboxamide
CAS No.:175201-98-6
Molecular Formula:C₉H₉ClN₄O
Molecular Weight:224.65
Hs Code.:2933998090
DSSTox Substance ID:DTXSID80370910
Wikidata:Q82158090
Mol file:175201-98-6.mol

Synonyms:175201-98-6;4-Chloro-1,3-Dimethyl-1H-Pyrazolo[3,4-B]Pyridine-5-Carboxamide;4-chloro-1,3-dimethylpyrazolo[3,4-b]pyridine-5-carboxamide;1H-Pyrazolo[3,4-b]pyridine-5-carboxamide, 4-chloro-1,3-dimethyl-;Oprea1_828883;SCHEMBL5717703;DTXSID80370910;PBNJVZMMMDZVIA-UHFFFAOYSA-N;MFCD00067963;FT-0617975;W-206153

Suppliers and Price of 4-Chloro-1,3-Dimethyl-1H-Pyrazolo[3,4-B]Pyridine-5-Carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXAMIDE 95.00%
1G
$ 655.62

Total 5 raw suppliers

Chemical Property of 4-Chloro-1,3-Dimethyl-1H-Pyrazolo[3,4-B]Pyridine-5-Carboxamide

Chemical Property:

Vapor Pressure:5.2E-07mmHg at 25°C
Melting Point:275 °C
XLogP3:0.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:224.0464886
Heavy Atom Count:15
Complexity:275

Purity/Quality:

98%Min ^*data from raw suppliers

4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NN(C2=NC=C(C(=C12)Cl)C(=O)N)C

Technology Process of 4-Chloro-1,3-Dimethyl-1H-Pyrazolo[3,4-B]Pyridine-5-Carboxamide

There total 5 articles about 4-Chloro-1,3-Dimethyl-1H-Pyrazolo[3,4-B]Pyridine-5-Carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 175201-95-3
4-Chloro-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride

: 175201-98-6
4-chloro-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide

Guidance literature:: With ammonium hydroxide;
DOI:10.1016/j.bmcl.2003.10.025

Reference yield:

: 3524-32-1
5-Amino-1,3-dimethylpyrazole

: 175201-98-6
4-chloro-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / 1 h / 120 °C

2: 77 percent / POCl₃ / 18 h / 120 °C

3: 99 percent / potassium hydroxide / H₂O; 1,2-dimethoxy-ethane / 18 h / 20 °C

4: SOCl₂ / 1 h / 80 °C

5: 1.98 g / aq. ammonium / tetrahydrofuran / 0.17 h / 0 °C

With potassium hydroxide; ammonium hydroxide; thionyl chloride; trichlorophosphate; In tetrahydrofuran; 1,2-dimethoxyethane; water;
DOI:10.1016/j.bmc.2004.05.032

Reference yield:

: 20481-15-6
ethyl 4-chloro-1,3-dimethylpyrazolo[3,4-b]pyridine-5-carboxylate

: 175201-98-6
4-chloro-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / potassium hydroxide / H₂O; 1,2-dimethoxy-ethane / 18 h / 20 °C

2: SOCl₂ / 1 h / 80 °C

3: 1.98 g / aq. ammonium / tetrahydrofuran / 0.17 h / 0 °C

With potassium hydroxide; ammonium hydroxide; thionyl chloride; In tetrahydrofuran; 1,2-dimethoxyethane; water;
DOI:10.1016/j.bmc.2004.05.032