1-biphenyl-4-yl-1'-[(1-methyl-1H-imidazol-2-yl)methyl]spiro[indole-3,4'-piperidin]-2(1H)-one

Base Information

Chemical Name:1-biphenyl-4-yl-1'-[(1-methyl-1H-imidazol-2-yl)methyl]spiro[indole-3,4'-piperidin]-2(1H)-one
CAS No.:1086280-00-3
Molecular Formula:C₂₉H₂₈N₄O
Molecular Weight:448.568
Hs Code.:

Synonyms:1-biphenyl-4-yl-1'-[(1-methyl-1H-imidazol-2-yl)methyl]spiro[indole-3,4'-piperidin]-2(1H)-one

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Chemical Property of 1-biphenyl-4-yl-1'-[(1-methyl-1H-imidazol-2-yl)methyl]spiro[indole-3,4'-piperidin]-2(1H)-one

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Technology Process of 1-biphenyl-4-yl-1'-[(1-methyl-1H-imidazol-2-yl)methyl]spiro[indole-3,4'-piperidin]-2(1H)-one

There total 4 articles about 1-biphenyl-4-yl-1'-[(1-methyl-1H-imidazol-2-yl)methyl]spiro[indole-3,4'-piperidin]-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1086282-02-1
C₂₄H₂₂N₂O

: 13750-81-7
N-methyl-2-imidazolcarboxaldehyde

: 1086280-00-3
1-biphenyl-4-yl-1'-[(1-methyl-1H-imidazol-2-yl)methyl]spiro[indole-3,4'-piperidin]-2(1H)-one

Guidance literature:: C₂₄H₂₂N₂O; N-methyl-2-imidazolcarboxaldehyde; With sodium tris(acetoxy)borohydride; In metrhylene chloride; at 20 ℃; for 2h;

With methanol; In dichloromethane; at 20 ℃; for 0.0833333h;

Reference yield:

: 252882-60-3
tert-butyl 2-oxo-1,2-dihydro-1'H-spiro[indole-3,4-piperidine]-1'-carboxylate

: 1086280-00-3
1-biphenyl-4-yl-1'-[(1-methyl-1H-imidazol-2-yl)methyl]spiro[indole-3,4'-piperidin]-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / acetonitrile / 15 h / 40 - 80 °C

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3.1: sodium tris(acetoxy)borohydride / metrhylene chloride / 2 h / 20 °C

3.2: 0.08 h / 20 °C

With hydrogenchloride; copper(l) iodide; sodium tris(acetoxy)borohydride; potassium carbonate; N,N`-dimethylethylenediamine; In 1,4-dioxane; metrhylene chloride; acetonitrile;

Reference yield:

: 59-48-3
2-oxoindole

: 1086280-00-3
1-biphenyl-4-yl-1'-[(1-methyl-1H-imidazol-2-yl)methyl]spiro[indole-3,4'-piperidin]-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / Dimethyl ether / 1.17 h / -78 - -30 °C

1.2: 48 h / -30 - 20 °C

2.1: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / acetonitrile / 15 h / 40 - 80 °C

3.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

4.1: sodium tris(acetoxy)borohydride / metrhylene chloride / 2 h / 20 °C

4.2: 0.08 h / 20 °C

With hydrogenchloride; copper(l) iodide; sodium tris(acetoxy)borohydride; potassium carbonate; lithium hexamethyldisilazane; N,N`-dimethylethylenediamine; In 1,4-dioxane; Dimethyl ether; metrhylene chloride; acetonitrile;