cis-2-chloro-3,4(S)-dimethyl-5(S)-phenyl-1,3,2-oxazaphospholidin-2-one

Base Information

• Chemical Name: cis-2-chloro-3,4(S)-dimethyl-5(S)-phenyl-1,3,2-oxazaphospholidin-2-one
• CAS No.: 149116-52-9
• Molecular Formula: C₁₀H₁₃ClNO₂P
• Molecular Weight: 245.645

Synonyms:cis-2-chloro-3,4(S)-dimethyl-5(S)-phenyl-1,3,2-oxazaphospholidin-2-one

Chemical Property of cis-2-chloro-3,4(S)-dimethyl-5(S)-phenyl-1,3,2-oxazaphospholidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-2-chloro-3,4(S)-dimethyl-5(S)-phenyl-1,3,2-oxazaphospholidin-2-one

There total 2 articles about cis-2-chloro-3,4(S)-dimethyl-5(S)-phenyl-1,3,2-oxazaphospholidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

(1S,2R)-(+)-ephedrine (321-98-2,7009-81-6,90-83-5,6912-63-6) → (2R,4R,5S)-2-Chloro-3,4-dimethyl-5-phenyl-[1,3,2]oxazaphospholidine 2-oxide (31060-10-3) + (2S,4R,5S)-2-Chloro-3,4-dimethyl-5-phenyl-[1,3,2]oxazaphospholidine 2-oxide (13897-77-3,28080-18-4,28080-19-5,31060-10-3,31060-12-5,53625-09-5,53625-11-9,54750-12-8,54750-13-9,72691-41-9,149116-52-9)

Guidance literature:

With trichlorophosphate; In benzene;

DOI:10.1021/jo00311a017

Reference yield:

pseudoephedrine (90-82-4,7009-81-6,90-83-5,6912-63-6) → (4S)-2-chloro-3,4r-dimethyl-5t-phenyl-[1,3,2]oxazaphospholidine 2ξ-oxide (13897-77-3,28080-18-4,28080-19-5,31060-10-3,31060-12-5,53625-09-5,53625-11-9,54750-12-8,54750-13-9,72691-41-9,149116-52-9)

Guidance literature:

With triethylamine; trichlorophosphate;

Reference yield: 77.0%

3-methylcyclohexen-2-one (1193-18-6) + (4S)-2-chloro-3,4r-dimethyl-5t-phenyl-[1,3,2]oxazaphospholidine 2ξ-oxide (13897-77-3,28080-18-4,28080-19-5,31060-10-3,31060-12-5,53625-09-5,53625-11-9,54750-12-8,54750-13-9,72691-41-9,149116-52-9) → (2S,4S,5S)-3,4-Dimethyl-2-((3-methyl-1,5-cyclohexenyl)-1-oxy)-5-phenyl-1,3,2-oxazaphospholidin-2-one

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; 1.) -78 deg C, 2 h, 2.) -78 deg C, 1 h; to r.t.;

DOI:10.1021/jo00105a042

upstream raw materials:

(1S,2R)-(+)-ephedrine

pseudoephedrine

Downstream raw materials:

(2R,4R,5S)-3,4-Dimethyl-2-(4-methoxyphenoxy)-5-phenyl-1,3,2-oxazaphospholidine 2-oxide

(2-Oxo-ethyl)-phosphonothioic acid O-((4S,5R)-3,4-dimethyl-2-oxo-5-phenyl-2λ⁵-[1,3,2]oxazaphospholidin-2-yl) ester

C₁₂H₁₇NO₄⁽¹⁸⁾OP₂S

C₁₂H₁₇NO₄⁽¹⁸⁾OP₂S

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 149116-52-9 cis-2-chloro-3,4(S)-dimethyl-5(S)-phenyl-1,3,2-oxazaphospholidin-2-one

Send

Send

Metric Ton KG G Pound L ML

Send

Send