(2R,4R,5S)-2-Chloro-3,4-dimethyl-5-phenyl-[1,3,2]oxazaphospholidine 2-oxide

Base Information

• Chemical Name: (2R,4R,5S)-2-Chloro-3,4-dimethyl-5-phenyl-[1,3,2]oxazaphospholidine 2-oxide
• CAS No.: 31060-10-3
• Molecular Formula: C₁₀H₁₃ClNO₂P
• Molecular Weight: 245.645

Synonyms:(2R,4R,5S)-2-Chloro-3,4-dimethyl-5-phenyl-[1,3,2]oxazaphospholidine 2-oxide

Chemical Property of (2R,4R,5S)-2-Chloro-3,4-dimethyl-5-phenyl-[1,3,2]oxazaphospholidine 2-oxide

Chemical Property:

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Technology Process of (2R,4R,5S)-2-Chloro-3,4-dimethyl-5-phenyl-[1,3,2]oxazaphospholidine 2-oxide

There total 4 articles about (2R,4R,5S)-2-Chloro-3,4-dimethyl-5-phenyl-[1,3,2]oxazaphospholidine 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(+)-(1S,2R)-ephedrine hydrochloride (24221-86-1) → (2R,4R,5S)-2-Chloro-3,4-dimethyl-5-phenyl-[1,3,2]oxazaphospholidine 2-oxide (31060-10-3)

Guidance literature:

With trichlorophosphate; In benzene; at -10 ℃; for 6h;

DOI:10.1021/jo971868j

Reference yield: 12.0%

(1S,2R)-(+)-ephedrine (321-98-2,7009-81-6,90-83-5,6912-63-6) → (2R,4R,5S)-2-Chloro-3,4-dimethyl-5-phenyl-[1,3,2]oxazaphospholidine 2-oxide (31060-10-3) + (2S,4R,5S)-2-Chloro-3,4-dimethyl-5-phenyl-[1,3,2]oxazaphospholidine 2-oxide (13897-77-3,28080-18-4,28080-19-5,31060-10-3,31060-12-5,53625-09-5,53625-11-9,54750-12-8,54750-13-9,72691-41-9,149116-52-9)

Guidance literature:

With trichlorophosphate; In benzene;

DOI:10.1021/jo00311a017

Reference yield: 12.0%

(1S,2R)-(+)-ephedrine (321-98-2,7009-81-6,90-83-5,6912-63-6) → (2R,4R,5S)-2-Chloro-3,4-dimethyl-5-phenyl-[1,3,2]oxazaphospholidine 2-oxide (31060-10-3) + (2S,4R,5S)-2-Chloro-3,4-dimethyl-5-phenyl-[1,3,2]oxazaphospholidine 2-oxide (13897-77-3,28080-18-4,28080-19-5,31060-10-3,31060-12-5,53625-09-5,53625-11-9,54750-12-8,54750-13-9,72691-41-9,149116-52-9)

Guidance literature:

With trichlorophosphate; In benzene;

DOI:10.1021/jo00311a017

upstream raw materials:

(1S,2R)-(+)-ephedrine

(+)-(1S,2R)-ephedrine hydrochloride

pseudoephedrine

Downstream raw materials:

(2S,4R,5S)-3,4-Dimethyl-2-(4-methoxyphenoxy)-5-phenyl-1,3,2-oxazaphospholidine 2-oxide

(2R,4R,5S)-3,4-Dimethyl-2-(4-methoxyphenoxy)-5-phenyl-1,3,2-oxazaphospholidine 2-oxide

(E)-2-((2S,4S,5S)-3,4-Dimethyl-2-oxo-5-phenyl-2λ⁵-[1,3,2]oxazaphospholidin-2-yloxy)-pent-3-enenitrile

(E)-(R)-2-((2S,4S,5S)-3,4-Dimethyl-2-oxo-5-phenyl-2λ⁵-[1,3,2]oxazaphospholidin-2-yloxy)-2-((E)-3-phenyl-allyl)-pent-3-enenitrile

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