(+/-)-4-(1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenoxy)butyl)benzoic acid

Base Information

Chemical Name:(+/-)-4-(1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenoxy)butyl)benzoic acid
CAS No.:1393126-65-2
Molecular Formula:C₂₁H₁₉F₃N₂O₃
Molecular Weight:404.389
Hs Code.:

Synonyms:(+/-)-4-(1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenoxy)butyl)benzoic acid

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Chemical Property of (+/-)-4-(1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenoxy)butyl)benzoic acid

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Technology Process of (+/-)-4-(1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenoxy)butyl)benzoic acid

There total 4 articles about (+/-)-4-(1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenoxy)butyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1393126-64-1
(+/-)-methyl 4-(1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenoxy)butyl)benzoate

: 1393126-65-2
(+/-)-4-(1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenoxy)butyl)benzoic acid

Guidance literature:: (+/-)-methyl 4-(1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenoxy)butyl)benzoate; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 20h; Reflux;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; pH=2;

Reference yield:

: 1571-08-0
methyl 4-formylbenzoate

: 1393126-65-2
(+/-)-4-(1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenoxy)butyl)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 2.33 h / 0 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

3.1: potassium carbonate / copper(l) iodide; 8-quinolinol / dimethyl sulfoxide / 100 °C / Inert atmosphere

4.1: water; lithium hydroxide / tetrahydrofuran / 20 h / 20 °C / Reflux

4.2: 20 °C / pH 2

With di-isopropyl azodicarboxylate; water; potassium carbonate; triphenylphosphine; lithium hydroxide; copper(l) iodide; 8-quinolinol; In tetrahydrofuran; dimethyl sulfoxide; 1.1: Grignard Reaction / 2.1: Mitsunobu reaction;

Reference yield:

: 872254-79-0
4-(1-hydroxybutyl)benzoic acid methyl ester

: 1393126-65-2
(+/-)-4-(1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenoxy)butyl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

2.1: potassium carbonate / copper(l) iodide; 8-quinolinol / dimethyl sulfoxide / 100 °C / Inert atmosphere

3.1: water; lithium hydroxide / tetrahydrofuran / 20 h / 20 °C / Reflux

3.2: 20 °C / pH 2

With di-isopropyl azodicarboxylate; water; potassium carbonate; triphenylphosphine; lithium hydroxide; copper(l) iodide; 8-quinolinol; In tetrahydrofuran; dimethyl sulfoxide; 1.1: Mitsunobu reaction;