(+/-)-methyl 3-(4-(1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenoxy)butyl)benzamido)propanoate

Base Information

Chemical Name:(+/-)-methyl 3-(4-(1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenoxy)butyl)benzamido)propanoate
CAS No.:1393126-66-3
Molecular Formula:C₂₅H₂₆F₃N₃O₄
Molecular Weight:489.494
Hs Code.:

Synonyms:(+/-)-methyl 3-(4-(1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenoxy)butyl)benzamido)propanoate

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Chemical Property of (+/-)-methyl 3-(4-(1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenoxy)butyl)benzamido)propanoate

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Technology Process of (+/-)-methyl 3-(4-(1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenoxy)butyl)benzamido)propanoate

There total 5 articles about (+/-)-methyl 3-(4-(1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenoxy)butyl)benzamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1393126-65-2
(+/-)-4-(1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenoxy)butyl)benzoic acid

: 3196-73-4
methyl 3-aminopropanoate hydrochloride

: 1393126-66-3
(+/-)-methyl 3-(4-(1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenoxy)butyl)benzamido)propanoate

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 1571-08-0
methyl 4-formylbenzoate

: 1393126-66-3
(+/-)-methyl 3-(4-(1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenoxy)butyl)benzamido)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 2.33 h / 0 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

3.1: potassium carbonate / copper(l) iodide; 8-quinolinol / dimethyl sulfoxide / 100 °C / Inert atmosphere

4.1: water; lithium hydroxide / tetrahydrofuran / 20 h / 20 °C / Reflux

4.2: 20 °C / pH 2

5.1: 1-hydroxy-7-aza-benzotriazole; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With 1-hydroxy-7-aza-benzotriazole; di-isopropyl azodicarboxylate; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; lithium hydroxide; copper(l) iodide; 8-quinolinol; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 1.1: Grignard Reaction / 2.1: Mitsunobu reaction;

Reference yield:

: 872254-79-0
4-(1-hydroxybutyl)benzoic acid methyl ester

: 1393126-66-3
(+/-)-methyl 3-(4-(1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenoxy)butyl)benzamido)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

2.1: potassium carbonate / copper(l) iodide; 8-quinolinol / dimethyl sulfoxide / 100 °C / Inert atmosphere

3.1: water; lithium hydroxide / tetrahydrofuran / 20 h / 20 °C / Reflux

3.2: 20 °C / pH 2

4.1: 1-hydroxy-7-aza-benzotriazole; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With 1-hydroxy-7-aza-benzotriazole; di-isopropyl azodicarboxylate; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; lithium hydroxide; copper(l) iodide; 8-quinolinol; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 1.1: Mitsunobu reaction;