(+/-)-methyl 4-(1-hydroxybutyl)benzoate

Base Information

• Chemical Name: (+/-)-methyl 4-(1-hydroxybutyl)benzoate
• CAS No.: 872254-79-0
• Molecular Formula: C12H16O3
• Molecular Weight: 208.257
• Mol file: 872254-79-0.mol

Synonyms:4-(1-hydroxy-butyl)-benzoic acid methyl ester;methyl 4-(1-hydroxybutyl)benzoate;

Chemical Property of (+/-)-methyl 4-(1-hydroxybutyl)benzoate

Chemical Property:

• PSA: 46.53000
• LogP: 2.30670

Purity/Quality:

97-99% ^*data from raw suppliers

Methyl4-(1-hydroxybutyl)benzoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (+/-)-methyl 4-(1-hydroxybutyl)benzoate

There total 8 articles about (+/-)-methyl 4-(1-hydroxybutyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

n-propylmagnesium bromide (927-77-5) + methyl 4-formylbenzoate (1571-08-0) → 4-(1-hydroxybutyl)benzoic acid methyl ester (872254-79-0)

Guidance literature:

In tetrahydrofuran; at -78 - 20 ℃; for 3h;

Reference yield: 48.0%

methyl o-formylbenzoate (4122-56-9) + 1-propylmagnesium chloride (2234-82-4) → 4-(1-hydroxybutyl)benzoic acid methyl ester (872254-79-0)

Guidance literature:

methyl o-formylbenzoate; 1-propylmagnesium chloride; In tetrahydrofuran; diethyl ether; at 0 ℃; for 0.75h;

With hydrogenchloride; In tetrahydrofuran; diethyl ether; water;

Reference yield: 44.0%

1-propylmagnesium chloride (2234-82-4) + methyl 4-formylbenzoate (1571-08-0) → 4-(1-hydroxybutyl)benzoic acid methyl ester (872254-79-0)

Guidance literature:

methyl 4-formylbenzoate; With titanium tetrachloride; In tetrahydrofuran; at -50 ℃;

1-propylmagnesium chloride; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 2h;

upstream raw materials:

methyl o-formylbenzoate

1-propylmagnesium chloride

4-butyrylbenzoic acid methyl ester

methyl 4-formylbenzoate

Downstream raw materials:

methyl 4-(1-bromobutyl)benzoate

4-[1-(6-chloro-pyridin-3-yloxy)-butyl]-benzoic acid methyl ester

4-[1-(3-nitro-pyrazol-1-yl)-butyl]-benzoic acid methyl ester

4-[1-(3-amino-pyrazol-1-yl)-butyl]-benzoic acid methyl ester

Refernces

• 1、 -. "QUINOLINYL GLUCAGON RECEPTOR MODULATORS". Page/Page column 62. . Retrieved 2013/03/26.
• 2、 -. "GLUCAGON RECEPTOR ANTAGONISTS". Page/Page column 50. . Retrieved 2010/04/03.