N-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-2-fluorobenzenesulfonamide

Base Information

Chemical Name:N-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-2-fluorobenzenesulfonamide
CAS No.:1192298-61-5
Molecular Formula:C₂₃H₁₈F₂N₂O₅S
Molecular Weight:472.469
Hs Code.:

Synonyms:N-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-2-fluorobenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-2-fluorobenzenesulfonamide

Chemical Property:

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Technology Process of N-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-2-fluorobenzenesulfonamide

There total 5 articles about N-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-2-fluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 2905-21-7
2-fluorobenzenesulfonyl chloride

: 228559-74-8
4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-fluoroaniline

: 1192298-61-5
N-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-2-fluorobenzenesulfonamide

Guidance literature:: With pyridine; at 20 ℃; for 48h;
DOI:10.1021/acs.jmedchem.8b00672

Reference yield: 51.0%

: 1192298-61-5
N-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-2-fluorobenzenesulfonamide

Guidance literature:

Reference yield:

: 35654-56-9
6,7-dimethoxy-4-chloroquinoline

: 1192298-61-5
N-[4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]-2-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / chlorobenzene / 48 h / Reflux

2: ammonium chloride; zinc / ethanol; water / 3 h / Reflux

3: pyridine / 48 h / 20 °C

With pyridine; ammonium chloride; N-ethyl-N,N-diisopropylamine; zinc; In ethanol; water; chlorobenzene;
DOI:10.1021/acs.jmedchem.8b00672