2-{4-[2-(2-biphenyl-4-yl-5-trifluoromethyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid

Base Information

Chemical Name:2-{4-[2-(2-biphenyl-4-yl-5-trifluoromethyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid
CAS No.:328918-72-5
Molecular Formula:C₂₈H₂₄F₃NO₅
Molecular Weight:511.497
Hs Code.:

Synonyms:2-{4-[2-(2-biphenyl-4-yl-5-trifluoromethyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid

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Chemical Property of 2-{4-[2-(2-biphenyl-4-yl-5-trifluoromethyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid

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Technology Process of 2-{4-[2-(2-biphenyl-4-yl-5-trifluoromethyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid

There total 8 articles about 2-{4-[2-(2-biphenyl-4-yl-5-trifluoromethyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 328920-00-9
2-{4-[2-(2-biphenyl-4-yl-5-trifluoromethyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid methyl ester

: 328918-72-5
2-{4-[2-(2-biphenyl-4-yl-5-trifluoromethyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid

Guidance literature:: With sodium hydroxide; In ethanol; at 50 ℃; for 1h;
DOI:10.1021/jo026655v

Reference yield:

: 42806-90-6
2-(4-hydroxyphenoxy)-2-methyl propionic acid ethyl ester

: 328918-72-5
2-{4-[2-(2-biphenyl-4-yl-5-trifluoromethyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: 83.9 percent / K₂CO₃; sodium sulfate / ethanol / 10 h / Heating

2.1: NaH / dimethylformamide / 1.5 h / 20 °C

2.2: 89 percent / dimethylformamide / 70 °C

3.1: aq. NaOH / ethanol / 0.75 h / Heating

3.2: 63 percent / conc. HCl / ethanol / 16 h / pH 1 / Heating

4.1: 64 percent / NaHB(OAc)3 / CH₂Cl₂ / 4 h / 20 °C

5.1: 100 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

6.1: 100 percent / aq. NaOH / dioxane / 7 h / 60 °C

7.1: pyridine / toluene / 9 h / Heating

7.2: 141 mg / diethyl ether

8.1: 98 percent / aq. NaOH / ethanol / 1 h / 50 °C

With pyridine; sodium hydroxide; sodium tris(acetoxy)borohydride; sodium hydride; potassium carbonate; sodium sulfate; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 7.1: Robinson-Gabriel reaction;
DOI:10.1021/jo026655v

Reference yield:

: 518343-90-3
2-[4-(2-bromoethoxy)-phenoxy]-2-methyl-propionic acid ethyl ester

: 328918-72-5
2-{4-[2-(2-biphenyl-4-yl-5-trifluoromethyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaH / dimethylformamide / 1.5 h / 20 °C

1.2: 89 percent / dimethylformamide / 70 °C

2.1: aq. NaOH / ethanol / 0.75 h / Heating

2.2: 63 percent / conc. HCl / ethanol / 16 h / pH 1 / Heating

3.1: 64 percent / NaHB(OAc)3 / CH₂Cl₂ / 4 h / 20 °C

4.1: 100 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

5.1: 100 percent / aq. NaOH / dioxane / 7 h / 60 °C

6.1: pyridine / toluene / 9 h / Heating

6.2: 141 mg / diethyl ether

7.1: 98 percent / aq. NaOH / ethanol / 1 h / 50 °C

With pyridine; sodium hydroxide; sodium tris(acetoxy)borohydride; sodium hydride; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 6.1: Robinson-Gabriel reaction;
DOI:10.1021/jo026655v