2-{4-[2-(2-biphenyl-4-yl-5-trifluoromethyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid methyl ester

Base Information

Chemical Name:2-{4-[2-(2-biphenyl-4-yl-5-trifluoromethyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid methyl ester
CAS No.:328920-00-9
Molecular Formula:C₂₉H₂₆F₃NO₅
Molecular Weight:525.524
Hs Code.:

Synonyms:2-{4-[2-(2-biphenyl-4-yl-5-trifluoromethyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid methyl ester

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Chemical Property of 2-{4-[2-(2-biphenyl-4-yl-5-trifluoromethyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid methyl ester

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Technology Process of 2-{4-[2-(2-biphenyl-4-yl-5-trifluoromethyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid methyl ester

There total 8 articles about 2-{4-[2-(2-biphenyl-4-yl-5-trifluoromethyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 60-29-7,927820-24-4
diethyl ether

: 70-25-7
N-Methyl-N'-nitro-N-nitrosoguanidine

: 328918-72-5
2-{4-[2-(2-biphenyl-4-yl-5-trifluoromethyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid

: 518344-02-0
2-[benzyl-(biphenyl-4-carbonyl)-amino]-4-[4-(1-carboxy-1-methyl-ethoxy)-phenoxy]-butyric acid

: 328920-00-9
2-{4-[2-(2-biphenyl-4-yl-5-trifluoromethyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid methyl ester

Guidance literature:: With pyridine; potassium hydroxide; trifluoroacetic anhydride; In dichloromethane; toluene;

Reference yield:

: 42806-90-6
2-(4-hydroxyphenoxy)-2-methyl propionic acid ethyl ester

: 328920-00-9
2-{4-[2-(2-biphenyl-4-yl-5-trifluoromethyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 83.9 percent / K₂CO₃; sodium sulfate / ethanol / 10 h / Heating

2.1: NaH / dimethylformamide / 1.5 h / 20 °C

2.2: 89 percent / dimethylformamide / 70 °C

3.1: aq. NaOH / ethanol / 0.75 h / Heating

3.2: 63 percent / conc. HCl / ethanol / 16 h / pH 1 / Heating

4.1: 64 percent / NaHB(OAc)3 / CH₂Cl₂ / 4 h / 20 °C

5.1: 100 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

6.1: 100 percent / aq. NaOH / dioxane / 7 h / 60 °C

7.1: pyridine / toluene / 9 h / Heating

7.2: 141 mg / diethyl ether

With pyridine; sodium hydroxide; sodium tris(acetoxy)borohydride; sodium hydride; potassium carbonate; sodium sulfate; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 7.1: Robinson-Gabriel reaction;
DOI:10.1021/jo026655v

Reference yield:

: 518343-90-3
2-[4-(2-bromoethoxy)-phenoxy]-2-methyl-propionic acid ethyl ester

: 328920-00-9
2-{4-[2-(2-biphenyl-4-yl-5-trifluoromethyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaH / dimethylformamide / 1.5 h / 20 °C

1.2: 89 percent / dimethylformamide / 70 °C

2.1: aq. NaOH / ethanol / 0.75 h / Heating

2.2: 63 percent / conc. HCl / ethanol / 16 h / pH 1 / Heating

3.1: 64 percent / NaHB(OAc)3 / CH₂Cl₂ / 4 h / 20 °C

4.1: 100 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

5.1: 100 percent / aq. NaOH / dioxane / 7 h / 60 °C

6.1: pyridine / toluene / 9 h / Heating

6.2: 141 mg / diethyl ether

With pyridine; sodium hydroxide; sodium tris(acetoxy)borohydride; sodium hydride; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 6.1: Robinson-Gabriel reaction;
DOI:10.1021/jo026655v