fluoromalonic acid diphenylmethyl tert-butyl ester

Base Information

Chemical Name:fluoromalonic acid diphenylmethyl tert-butyl ester
CAS No.:1277102-49-4
Molecular Formula:C₂₀H₂₁FO₄
Molecular Weight:344.383
Hs Code.:

Synonyms:fluoromalonic acid diphenylmethyl tert-butyl ester

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Chemical Property of fluoromalonic acid diphenylmethyl tert-butyl ester

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Technology Process of fluoromalonic acid diphenylmethyl tert-butyl ester

There total 2 articles about fluoromalonic acid diphenylmethyl tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₇H₁₁FO₄

: 776-74-9
Bromodiphenylmethane

: 1277102-49-4
fluoromalonic acid diphenylmethyl tert-butyl ester

Guidance literature:: With triethylamine; In acetonitrile; for 4h; Reflux;
DOI:10.1021/ja110349a

Reference yield:

: 1277102-70-1
fluoromalonic acid tert-butyl methyl ester

: 1277102-49-4
fluoromalonic acid diphenylmethyl tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / ethanol; water / 0.67 h

2: triethylamine / acetonitrile / 4 h / Reflux

With triethylamine; lithium hydroxide; In ethanol; water; acetonitrile;
DOI:10.1021/ja110349a

Reference yield: 99.0%

: 1277102-49-4
fluoromalonic acid diphenylmethyl tert-butyl ester

: 100-39-0
benzyl bromide

: 1277102-69-8
(R)-benzyl(fluoro)malonic acid diphenylmethyl tert-butyl ester

Guidance literature:: With (11bS,11b’S)-2,6-bis(3,4,5-trifluorophenyl)-3,3’,5,5’-tetrahydro-4,4’-spirobi[dinaphtho[2,1-c:1’,2’-e]azepin]-4-ium bromide; cesium hydroxide; In toluene; at -78 ℃; for 90h; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/ja110349a