Technology Process of diethyl 2-acetamido-2-(3,4-dichloro-5-iodobenzyl)malonate
There total 5 articles about diethyl 2-acetamido-2-(3,4-dichloro-5-iodobenzyl)malonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-acetylaminomalonic acid diethyl ester;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 5 ℃;
for 0.5h;
Inert atmosphere;
1,2-dichloro-3-iodo-5-methylbenzene;
With
N-Bromosuccinimide; dibenzoyl peroxide;
In
tetrachloromethane;
for 4h;
Reflux;
In
tetrachloromethane; N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
for 16h;
Inert atmosphere;
DOI:10.1016/j.bmc.2009.07.021
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogenchloride; iron / ethanol; water / 1.5 h / Reflux
2.1: sulfuric acid; sodium nitrite / acetic acid / 25 - 75 °C
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 5 °C / Inert atmosphere
3.2: 4 h / Reflux
3.3: 16 h / 20 °C / Inert atmosphere
With
hydrogenchloride; sulfuric acid; iron; sodium hydride; sodium nitrite;
In
ethanol; water; acetic acid; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2009.07.021
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tert.-butylnitrite; copper dichloride / acetonitrile / 1.5 h / 65 °C
2.1: hydrogenchloride; iron / ethanol; water / 1.5 h / Reflux
3.1: sulfuric acid; sodium nitrite / acetic acid / 25 - 75 °C
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 5 °C / Inert atmosphere
4.2: 4 h / Reflux
4.3: 16 h / 20 °C / Inert atmosphere
With
hydrogenchloride; tert.-butylnitrite; sulfuric acid; iron; sodium hydride; copper dichloride; sodium nitrite;
In
ethanol; water; acetic acid; N,N-dimethyl-formamide; acetonitrile; mineral oil;
1.1: Sandmeyer reaction;
DOI:10.1016/j.bmc.2009.07.021
