Technology Process of acetylamino-(3,4-dichloro-benzyl)-malonic acid diethyl ester
There total 8 articles about acetylamino-(3,4-dichloro-benzyl)-malonic acid diethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium ethanolate;
In
ethanol;
- Guidance literature:
-
diethyl 2-acetamido-2-(3,4-dichloro-5-iodobenzyl)malonate;
With
bis-triphenylphosphine-palladium(II) chloride;
In
1,2-dimethoxyethane;
at 20 ℃;
for 0.25h;
Inert atmosphere;
With
5-cyanothiophen-2-ylboronic acid; triethylamine;
In
1,2-dimethoxyethane; water;
at 20 ℃;
Inert atmosphere;
DOI:10.1016/j.bmc.2009.07.021
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 5 °C / Inert atmosphere
1.2: 4 h / Reflux
1.3: 16 h / 20 °C / Inert atmosphere
2.1: bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane / 0.25 h / 20 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; sodium hydride;
In
1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2009.07.021
