(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)acetaldehyde

Base Information

Chemical Name:(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)acetaldehyde
CAS No.:24953-96-6
Molecular Formula:C₁₂H₁₂O₅
Molecular Weight:236.224
Hs Code.:

Synonyms:(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)acetaldehyde

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Chemical Property of (4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)acetaldehyde

Chemical Property:

Purity/Quality:

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Technology Process of (4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)acetaldehyde

There total 1 articles about (4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24953-96-6
(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)acetaldehyde

: 123-76-2
levulinic acid

Guidance literature:: With chloroform; ozone; Anschliessend erwaermen mit Wasser;

Reference yield:

: 24953-96-6
(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)acetaldehyde

: 24280-93-1
mycophenolic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 2 h / Ambient temperature

2: 67 percent / tetrahydrofuran / 0.67 h / -40 °C

3: pivalic acid / xylene / 6 h / 135 - 140 °C

4: PPTS / 2-methyl-propan-2-ol / 6 h / 80 °C

5: 98 percent / aq. LiOH / methanol / 12 h

With lithium hydroxide; pyridinium p-toluenesulfonate; N-ethyl-N,N-diisopropylamine; Trimethylacetic acid; In tetrahydrofuran; methanol; dichloromethane; xylene; tert-butyl alcohol;
DOI:10.1139/v97-078

Reference yield:

: 24953-96-6
(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)acetaldehyde

: 32483-51-5,13312-25-9
ethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-isobenzofuran-5-yl)-4-methylhex-4-enoate

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 2 h / Ambient temperature

2: 67 percent / tetrahydrofuran / 0.67 h / -40 °C

3: pivalic acid / xylene / 6 h / 135 - 140 °C

4: PPTS / 2-methyl-propan-2-ol / 6 h / 80 °C

With pyridinium p-toluenesulfonate; N-ethyl-N,N-diisopropylamine; Trimethylacetic acid; In tetrahydrofuran; dichloromethane; xylene; tert-butyl alcohol;
DOI:10.1139/v97-078