2-fluoro-N-(3-((2E)-3-(3-(1,2,3,6-tetrahydro-1-methylpyridin-4-yl)-2,4,6-trimethoxyphenyl)acryloyl)phenyl)benzamide

Base Information

Chemical Name:2-fluoro-N-(3-((2E)-3-(3-(1,2,3,6-tetrahydro-1-methylpyridin-4-yl)-2,4,6-trimethoxyphenyl)acryloyl)phenyl)benzamide
CAS No.:1366408-12-9
Molecular Formula:C₃₁H₃₁FN₂O₅
Molecular Weight:530.596
Hs Code.:

Synonyms:2-fluoro-N-(3-((2E)-3-(3-(1,2,3,6-tetrahydro-1-methylpyridin-4-yl)-2,4,6-trimethoxyphenyl)acryloyl)phenyl)benzamide

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Chemical Property of 2-fluoro-N-(3-((2E)-3-(3-(1,2,3,6-tetrahydro-1-methylpyridin-4-yl)-2,4,6-trimethoxyphenyl)acryloyl)phenyl)benzamide

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Technology Process of 2-fluoro-N-(3-((2E)-3-(3-(1,2,3,6-tetrahydro-1-methylpyridin-4-yl)-2,4,6-trimethoxyphenyl)acryloyl)phenyl)benzamide

There total 5 articles about 2-fluoro-N-(3-((2E)-3-(3-(1,2,3,6-tetrahydro-1-methylpyridin-4-yl)-2,4,6-trimethoxyphenyl)acryloyl)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 303091-99-8
N-(3-acetylphenyl)-2-fluorobenzamide

: 1361455-25-5
3-(1,2,3,6-tetrahydro-1-methylpyridin-4-yl)-2,4,6-trimethoxybenzaldehyde

: 1366408-12-9
2-fluoro-N-(3-((2E)-3-(3-(1,2,3,6-tetrahydro-1-methylpyridin-4-yl)-2,4,6-trimethoxyphenyl)acryloyl)phenyl)benzamide

Guidance literature:: C₁₅H₁₂FNO₂; With sodium hydroxide; In ethanol; for 0.0833333h;

3-(1,2,3,6-tetrahydro-1-methylpyridin-4-yl)-2,4,6-trimethoxybenzaldehyde; In ethanol; at 20 ℃; for 24h;
DOI:10.3109/14756366.2011.587416

Reference yield:

: 113225-07-3
1-methyl-4-(2,4,6-trimethoxyphenyl)-1,2,3,6-tetrahydropyridine

: 1366408-12-9
2-fluoro-N-(3-((2E)-3-(3-(1,2,3,6-tetrahydro-1-methylpyridin-4-yl)-2,4,6-trimethoxyphenyl)acryloyl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / 2.5 h / 0 - 25 °C

1.2: Cooling with ice

2.1: sodium hydroxide / ethanol / 0.08 h

2.2: 24 h / 20 °C

With sodium hydroxide; trichlorophosphate; In ethanol; 1.1: Vilsmeier-Haack reaction / 1.2: Vilsmeier-Haack reaction / 2.1: Claisen-Schmidt condensation;
DOI:10.3109/14756366.2011.587416

Reference yield:

: 1445-73-4
1-Methyl-4-piperidone

: 1366408-12-9
2-fluoro-N-(3-((2E)-3-(3-(1,2,3,6-tetrahydro-1-methylpyridin-4-yl)-2,4,6-trimethoxyphenyl)acryloyl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; acetic acid / 3.5 h / 85 - 90 °C

2.1: trichlorophosphate / 2.5 h / 0 - 25 °C

2.2: Cooling with ice

3.1: sodium hydroxide / ethanol / 0.08 h

3.2: 24 h / 20 °C

With hydrogenchloride; acetic acid; sodium hydroxide; trichlorophosphate; In ethanol; 2.1: Vilsmeier-Haack reaction / 2.2: Vilsmeier-Haack reaction / 3.1: Claisen-Schmidt condensation;
DOI:10.3109/14756366.2011.587416