(E)-methyl 1-(1-bromo-2-(3-methoxyphenyl)vinyl)-1H-indole-3-carboxylate

Base Information

Chemical Name:(E)-methyl 1-(1-bromo-2-(3-methoxyphenyl)vinyl)-1H-indole-3-carboxylate
CAS No.:1432655-43-0
Molecular Formula:C₁₉H₁₆BrNO₃
Molecular Weight:386.245
Hs Code.:

Synonyms:(E)-methyl 1-(1-bromo-2-(3-methoxyphenyl)vinyl)-1H-indole-3-carboxylate

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Chemical Property of (E)-methyl 1-(1-bromo-2-(3-methoxyphenyl)vinyl)-1H-indole-3-carboxylate

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Technology Process of (E)-methyl 1-(1-bromo-2-(3-methoxyphenyl)vinyl)-1H-indole-3-carboxylate

There total 4 articles about (E)-methyl 1-(1-bromo-2-(3-methoxyphenyl)vinyl)-1H-indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1432655-47-4
methyl 1-((3-methoxyphenyl)ethynyl)-1H-indole-3-carboxylate

: 1432655-43-0
(E)-methyl 1-(1-bromo-2-(3-methoxyphenyl)vinyl)-1H-indole-3-carboxylate

Guidance literature:: methyl 1-((3-methoxyphenyl)ethynyl)-1H-indole-3-carboxylate; With trimethylsilyl bromide; In dichloromethane; at -78 ℃; for 0.25h; Inert atmosphere;

With water; In dichloromethane; at 20 ℃; for 0.833333h; stereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tetlet.2013.03.107

Reference yield:

: 942-24-5
3-methoxycarbonylindole

: 1432655-43-0
(E)-methyl 1-(1-bromo-2-(3-methoxyphenyl)vinyl)-1H-indole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,10-Phenanthroline; potassium carbonate; copper(ll) sulfate pentahydrate / tetrahydrofuran / 80 °C / Inert atmosphere

2.1: trimethylsilyl bromide / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

2.2: 0.83 h / 20 °C / Inert atmosphere

With 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; trimethylsilyl bromide; potassium carbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetlet.2013.03.107

Reference yield:

: 768-70-7
1-ethynyl-3-methoxybenzene

: 1432655-43-0
(E)-methyl 1-(1-bromo-2-(3-methoxyphenyl)vinyl)-1H-indole-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide; silver nitrate / acetone / 20 °C / Inert atmosphere

2.1: 1,10-Phenanthroline; potassium carbonate; copper(ll) sulfate pentahydrate / tetrahydrofuran / 80 °C / Inert atmosphere

3.1: trimethylsilyl bromide / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

3.2: 0.83 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; trimethylsilyl bromide; potassium carbonate; silver nitrate; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1016/j.tetlet.2013.03.107