{tert-butoxycarbonylmethyl-[1-hydroxymethyl-4-(4-nitrophenyl)butyl]amino}acetic acid tert-butyl ester

Base Information

• Chemical Name: {tert-butoxycarbonylmethyl-[1-hydroxymethyl-4-(4-nitrophenyl)butyl]amino}acetic acid tert-butyl ester
• CAS No.: 1142811-83-3
• Molecular Formula: C₂₃H₃₆N₂O₇
• Molecular Weight: 452.548
• Mol file: 1142811-83-3.mol

Synonyms:{tert-butoxycarbonylmethyl-[1-hydroxymethyl-4-(4-nitrophenyl)butyl]amino}acetic acid tert-butyl ester

Chemical Property of {tert-butoxycarbonylmethyl-[1-hydroxymethyl-4-(4-nitrophenyl)butyl]amino}acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {tert-butoxycarbonylmethyl-[1-hydroxymethyl-4-(4-nitrophenyl)butyl]amino}acetic acid tert-butyl ester

There total 9 articles about {tert-butoxycarbonylmethyl-[1-hydroxymethyl-4-(4-nitrophenyl)butyl]amino}acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

bromoacetic acid tert-butyl ester (5292-43-3) + 2-Amino-5-(4-nitrophenyl)-pentan-1-ol (1142811-85-5) → {tert-butoxycarbonylmethyl-[1-hydroxymethyl-4-(4-nitrophenyl)butyl]amino}acetic acid tert-butyl ester (1142811-83-3)

Guidance literature:

With potassium carbonate; In acetonitrile; at 0 - 20 ℃;

DOI:10.1039/c0cc05707j

Reference yield: 92.0%

→ {tert-butoxycarbonylmethyl-[1-hydroxymethyl-4-(4-nitrophenyl)butyl]amino}acetic acid tert-butyl ester (1142811-83-3) + trastuzumab

Guidance literature:

Reference yield:

1-bromo-3-(4-nitrophenyl)propane (53712-77-9) → {tert-butoxycarbonylmethyl-[1-hydroxymethyl-4-(4-nitrophenyl)butyl]amino}acetic acid tert-butyl ester (1142811-83-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium ethanolate / ethanol / 1.67 h / 50 °C / Reflux

1.2: 108 h / Reflux

1.3: 24 h / Reflux

2.1: hydrogenchloride / 0 - 20 °C

3.1: triethylamine / methanol; diethyl ether / 1 h / -10 °C

4.1: sodium tetrahydroborate / methanol / 0 - 20 °C

5.1: potassium carbonate / acetonitrile / 0 - 20 °C

With hydrogenchloride; sodium tetrahydroborate; sodium ethanolate; potassium carbonate; triethylamine; In methanol; diethyl ether; ethanol; acetonitrile;

DOI:10.1039/c0cc05707j

upstream raw materials:

bromoacetic acid tert-butyl ester

2-Amino-5-(4-nitrophenyl)-pentan-1-ol

2-amino-5-(4-nitrophenyl)pentanoic acid methyl ester

2-amino-5-(4-nitrophenyl)pentanoic acid

Downstream raw materials:

1,1-bis[2-(tert-butoxy)-2-oxoethyl]-2-[3-(4-nitrophenyl)propyl]aziridin-1-ium bromide

di-tert-butyl 2,2'-(2-bromo-5-(4-nitrophenyl)pentylazanediyl)diacetate

{4-[2-(bis-carboxymethylamino)-5-(4-isothiocyanatophenyl) pentyl]-7-carboxymethyl-[1,4,7]triazonan-1-yl}acetic acid

tert-butyl 2-{[2-(tert-butoxy)-2-oxoethyl][2-iodo-5-(4-nitrophenyl)pentyl]amino}acetate