2-chloro-3-fluoro-4-methoxybenzaldehyde

Base Information

• Chemical Name: 2-chloro-3-fluoro-4-methoxybenzaldehyde
• CAS No.: 1002344-90-2
• Molecular Formula: C₈H₆ClFO₂
• Molecular Weight: 188.586
• Hs Code.: 2913000090
• Mol file: 1002344-90-2.mol

Synonyms:2-chloro-3-fluoro-4-methoxybenzaldehyde

Chemical Property of 2-chloro-3-fluoro-4-methoxybenzaldehyde

Chemical Property:

• Boiling Point: 280.5±35.0 °C(Predicted)
• Density: 1.334±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-3-fluoro-4-methoxybenzaldehyde 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-3-fluoro-4-methoxybenzaldehyde

There total 2 articles about 2-chloro-3-fluoro-4-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-chloro-2-fluoro-3-methoxy-benzene (261762-56-5) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-chloro-3-fluoro-4-methoxybenzaldehyde (1002344-90-2)

Guidance literature:

1-chloro-2-fluoro-3-methoxy-benzene; With n-butyllithium; In tetrahydrofuran; hexane; at -70 ℃; for 1h;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -70 ℃; for 1h;

With hydrogenchloride; water; In tetrahydrofuran; hexane; at -70 - 20 ℃; for 18h;

Reference yield:

1-chloro-2-fluoro-3-methoxy-benzene (261762-56-5) + Dichloromethyl methyl ether (4885-02-3) → 2-chloro-3-fluoro-4-methoxybenzaldehyde (1002344-90-2)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;

Reference yield: 92.0%

5-amino-7-fluoroquinolin-2(1H)-one (950519-74-1) + 2-chloro-3-fluoro-4-methoxybenzaldehyde (1002344-90-2) → (E)-5-{[1-(2-chloro-3-fluoro-4-methoxyphenyl)methylidene]-amino}-7-fluoro-1H-quinolin-2-one

Guidance literature:

With titanium(IV) tetrabutoxide; acetic acid; In 1,4-dioxane; toluene; for 20h; Heating;

DOI:10.1016/j.bmcl.2020.127298

upstream raw materials:

1-chloro-2-fluoro-3-methoxy-benzene

N,N-dimethyl-formamide

Dichloromethyl methyl ether

Downstream raw materials:

5-{[1-(2-chloro-3-fluoro-4-methoxyphenyl)methylidene]-amino}-7-fluoro-1H-quinolin-2-one

5-{[(1S,2S)-1-(2-chloro-3-fluoro-4-methoxyphenyl)-3,3,3-trifluoro-2-hydroxy-2-(methoxymethyl)propyl]amino}-7-fluoro-1H-quinolin-2-one

Refernces

• 1、 -. "3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF". Paragraph 00301; 00302; 00303. . Retrieved 2017/09/27.
• 2、 -. "5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1-arylquinolin-2-ones, a Process for their Production and their Use as Anti-inflammatory Agents". Page/Page column 12. . Retrieved 2010/02/17.