1,1-dimethylethyl (3R)-3-{[5-(4-bromophenyl)-1H-1,2,3-triazol-1-yl]methyl}-1-pyrrolidinecarboxylate

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Chemical Name:1,1-dimethylethyl (3R)-3-{[5-(4-bromophenyl)-1H-1,2,3-triazol-1-yl]methyl}-1-pyrrolidinecarboxylate
CAS No.:1366767-75-0
Molecular Formula:C₁₈H₂₃BrN₄O₂
Molecular Weight:407.31
Hs Code.:

Synonyms:1,1-dimethylethyl (3R)-3-{[5-(4-bromophenyl)-1H-1,2,3-triazol-1-yl]methyl}-1-pyrrolidinecarboxylate

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Chemical Property of 1,1-dimethylethyl (3R)-3-{[5-(4-bromophenyl)-1H-1,2,3-triazol-1-yl]methyl}-1-pyrrolidinecarboxylate

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Technology Process of 1,1-dimethylethyl (3R)-3-{[5-(4-bromophenyl)-1H-1,2,3-triazol-1-yl]methyl}-1-pyrrolidinecarboxylate

There total 3 articles about 1,1-dimethylethyl (3R)-3-{[5-(4-bromophenyl)-1H-1,2,3-triazol-1-yl]methyl}-1-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 766-96-1
4-bromo-1-ethynylbenzene

: 1,1-dimethylethyl (3R)-3-(azidomethyl)-1-pyrrolidinecarboxylate

: 1366767-75-0
1,1-dimethylethyl (3R)-3-{[5-(4-bromophenyl)-1H-1,2,3-triazol-1-yl]methyl}-1-pyrrolidinecarboxylate

Guidance literature:: pentamethylcyclopentadienyl bis(triphenylphosphine)ruthenium(II) chloride; In 1,2-dichloro-ethane; at 80 ℃; for 8h;

Reference yield:

: 138108-72-2
tert-butyl (R)-3-hydroxymethylpyrrolidine-1-carboxylate

: 1366767-75-0
1,1-dimethylethyl (3R)-3-{[5-(4-bromophenyl)-1H-1,2,3-triazol-1-yl]methyl}-1-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

2: N-ethyl-N,N-diisopropylamine; sodium azide / dimethyl sulfoxide / 96 h

3: pentamethylcyclopentadienyl bis(triphenylphosphine)ruthenium(II) chloride / 1,2-dichloro-ethane / 8 h / 80 °C

With sodium azide; N-ethyl-N,N-diisopropylamine; pentamethylcyclopentadienyl bis(triphenylphosphine)ruthenium(II) chloride; In dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane;

Reference yield:

: 177947-76-1
(3R)-1-(tert-butoxycarbonyl)-3-[(methane-sulfonyloxy)methyl]pyrrolidine

: 1366767-75-0
1,1-dimethylethyl (3R)-3-{[5-(4-bromophenyl)-1H-1,2,3-triazol-1-yl]methyl}-1-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; sodium azide / dimethyl sulfoxide / 96 h

2: pentamethylcyclopentadienyl bis(triphenylphosphine)ruthenium(II) chloride / 1,2-dichloro-ethane / 8 h / 80 °C

With sodium azide; N-ethyl-N,N-diisopropylamine; pentamethylcyclopentadienyl bis(triphenylphosphine)ruthenium(II) chloride; In dimethyl sulfoxide; 1,2-dichloro-ethane;