Technology Process of (1R,5R)-9-benzyloxycarbonylamino-2-oxo-1-oxabicyclo[3.3.1]nonane
There total 7 articles about (1R,5R)-9-benzyloxycarbonylamino-2-oxo-1-oxabicyclo[3.3.1]nonane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium hypochlorite; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hydrogencarbonate; potassium bromide / water; acetone / 2.08 h / Cooling with ice
2: disodium hydrogenphosphate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 20 °C
With
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; disodium hydrogenphosphate; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; potassium bromide;
In
dichloromethane; water; acetone;
2: Bayer-Villiger oxidation;
DOI:10.1039/c2ob06984a
- Guidance literature:
-
Multi-step reaction with 5 steps
1: methanol / 20 °C
2: sodium hydroxide / dichloromethane; water
3: potassium carbonate / tetrahydrofuran / 16 h / 20 °C
4: sodium hypochlorite; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hydrogencarbonate; potassium bromide / water; acetone / 2.08 h / Cooling with ice
5: disodium hydrogenphosphate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 20 °C
With
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; disodium hydrogenphosphate; sodium hydrogencarbonate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; potassium bromide; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; acetone;
5: Bayer-Villiger oxidation;
DOI:10.1039/c2ob06984a
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium hydroxide / dichloromethane; water
2: potassium carbonate / tetrahydrofuran / 16 h / 20 °C
3: sodium hypochlorite; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hydrogencarbonate; potassium bromide / water; acetone / 2.08 h / Cooling with ice
4: disodium hydrogenphosphate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 20 °C
With
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; disodium hydrogenphosphate; sodium hydrogencarbonate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; potassium bromide; sodium hydroxide;
In
tetrahydrofuran; dichloromethane; water; acetone;
4: Bayer-Villiger oxidation;
DOI:10.1039/c2ob06984a
