Technology Process of benzyl (2R)-2-(2-(methoxy(methyl)amino)-2-oxoethyl)piperidine-1-carboxylate
There total 10 articles about benzyl (2R)-2-(2-(methoxy(methyl)amino)-2-oxoethyl)piperidine-1-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-methylcyclohexylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
at 20 ℃;
for 16h;
Inert atmosphere;
DOI:10.1039/c2ob06984a
- Guidance literature:
-
Multi-step reaction with 7 steps
1: methanol / 20 °C
2: sodium hydroxide / dichloromethane; water
3: potassium carbonate / tetrahydrofuran / 16 h / 20 °C
4: sodium hypochlorite; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hydrogencarbonate; potassium bromide / water; acetone / 2.08 h / Cooling with ice
5: disodium hydrogenphosphate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 20 °C
6: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 16 h / -78 °C
7: N-methylcyclohexylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C / Inert atmosphere
With
N-methylcyclohexylamine; triethylsilane; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; disodium hydrogenphosphate; boron trifluoride diethyl etherate; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; potassium bromide; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; acetone;
5: Bayer-Villiger oxidation;
DOI:10.1039/c2ob06984a
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium hydroxide / dichloromethane; water
2: potassium carbonate / tetrahydrofuran / 16 h / 20 °C
3: sodium hypochlorite; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hydrogencarbonate; potassium bromide / water; acetone / 2.08 h / Cooling with ice
4: disodium hydrogenphosphate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 20 °C
5: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 16 h / -78 °C
6: N-methylcyclohexylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C / Inert atmosphere
With
N-methylcyclohexylamine; triethylsilane; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; disodium hydrogenphosphate; boron trifluoride diethyl etherate; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; potassium bromide; sodium hydroxide;
In
tetrahydrofuran; dichloromethane; water; acetone;
4: Bayer-Villiger oxidation;
DOI:10.1039/c2ob06984a
