(E)-4-chloro-1-(cyclohexylmethyl)-3-(2-oxo-2-(pyridin-3-yl)ethylidene)indolin-2-one

Base Information

Chemical Name:(E)-4-chloro-1-(cyclohexylmethyl)-3-(2-oxo-2-(pyridin-3-yl)ethylidene)indolin-2-one
CAS No.:1310495-95-4
Molecular Formula:C₂₂H₂₁ClN₂O₂
Molecular Weight:380.874
Hs Code.:

Synonyms:(E)-4-chloro-1-(cyclohexylmethyl)-3-(2-oxo-2-(pyridin-3-yl)ethylidene)indolin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-4-chloro-1-(cyclohexylmethyl)-3-(2-oxo-2-(pyridin-3-yl)ethylidene)indolin-2-one

Chemical Property:

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Technology Process of (E)-4-chloro-1-(cyclohexylmethyl)-3-(2-oxo-2-(pyridin-3-yl)ethylidene)indolin-2-one

There total 4 articles about (E)-4-chloro-1-(cyclohexylmethyl)-3-(2-oxo-2-(pyridin-3-yl)ethylidene)indolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₃ClN₂O₃

: 1310495-95-4
(E)-4-chloro-1-(cyclohexylmethyl)-3-(2-oxo-2-(pyridin-3-yl)ethylidene)indolin-2-one

Guidance literature:: With methanesulfonyl chloride; In pyridine; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2010.12.037

Reference yield:

: 6344-05-4
4-chloroisatin

: 1310495-95-4
(E)-4-chloro-1-(cyclohexylmethyl)-3-(2-oxo-2-(pyridin-3-yl)ethylidene)indolin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 16 h / 20 °C

2: diethylamine / ethanol / 2 h / 20 °C

3: methanesulfonyl chloride / pyridine / 1 h / 20 °C

With potassium carbonate; methanesulfonyl chloride; diethylamine; potassium iodide; In pyridine; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2010.12.037

Reference yield:

: 350-03-8
methyl-3-pyridylketone

: 1291534-39-8
C₁₅H₁₆ClNO₂

: 1310495-95-4
(E)-4-chloro-1-(cyclohexylmethyl)-3-(2-oxo-2-(pyridin-3-yl)ethylidene)indolin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: diethylamine / ethanol / 2 h / 20 °C

2: methanesulfonyl chloride / pyridine / 1 h / 20 °C

With methanesulfonyl chloride; diethylamine; In pyridine; ethanol;
DOI:10.1016/j.bmcl.2010.12.037