2',3'-dihydro-4,5-dimethoxy-2'-p-toluenesulfonylspiro[isobenzofuran-1(3H),4'(1'H)-isoquinoline]-3-one

Base Information

Chemical Name:2',3'-dihydro-4,5-dimethoxy-2'-p-toluenesulfonylspiro[isobenzofuran-1(3H),4'(1'H)-isoquinoline]-3-one
CAS No.:173548-65-7
Molecular Formula:C₂₅H₂₃NO₆S
Molecular Weight:465.527
Hs Code.:

Synonyms:2',3'-dihydro-4,5-dimethoxy-2'-p-toluenesulfonylspiro[isobenzofuran-1(3H),4'(1'H)-isoquinoline]-3-one

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Chemical Property of 2',3'-dihydro-4,5-dimethoxy-2'-p-toluenesulfonylspiro[isobenzofuran-1(3H),4'(1'H)-isoquinoline]-3-one

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Technology Process of 2',3'-dihydro-4,5-dimethoxy-2'-p-toluenesulfonylspiro[isobenzofuran-1(3H),4'(1'H)-isoquinoline]-3-one

There total 1 articles about 2',3'-dihydro-4,5-dimethoxy-2'-p-toluenesulfonylspiro[isobenzofuran-1(3H),4'(1'H)-isoquinoline]-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 98-59-9
p-toluenesulfonyl chloride

: 2',3'-dihydro-4,5-dimethoxyspiro[isobenzofuran-1(3H),4'(1'H)-isoquinoline]-3-one hydrochloride

: 173548-65-7
2',3'-dihydro-4,5-dimethoxy-2'-p-toluenesulfonylspiro[isobenzofuran-1(3H),4'(1'H)-isoquinoline]-3-one

Guidance literature:: With triethylamine; In chloroform; for 1h; Ambient temperature;
DOI:10.1021/jm950707+

Reference yield: 99.0%

: 173548-65-7
2',3'-dihydro-4,5-dimethoxy-2'-p-toluenesulfonylspiro[isobenzofuran-1(3H),4'(1'H)-isoquinoline]-3-one

: 173548-66-8
3,4-dimethoxy-6-[(2-p-toluenesulfonyl-1,2,3,4-tetrahydroisoquinoline)-4-yl]benzoic acid

Guidance literature:: With hydrogen; acetic acid; palladium 10% on activated carbon; at 20 ℃; for 48h; under 3345.86 Torr;

Reference yield:

: 173548-65-7
2',3'-dihydro-4,5-dimethoxy-2'-p-toluenesulfonylspiro[isobenzofuran-1(3H),4'(1'H)-isoquinoline]-3-one

: 173548-68-0
8,9-dimethoxy-2-(p-tolylsulfonyl)-2,3,7,11b-tetrahydro-1H-napth<1,2,3-de>isoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / acetic acid / 48 h / 2585.7 Torr / Ambient temperature

2: 81 percent / BH₃*THF / tetrahydrofuran / Heating

3: 82 percent / conc. H₂SO₄ / 2 h

With borane-THF; sulfuric acid; hydrogen; palladium on activated charcoal; In tetrahydrofuran; acetic acid;
DOI:10.1021/jm950707+