2-(((2-(3-(2-fluoroethoxy)-4-methoxyphenyl)-5-methylthiazol-4-yl)methyl)thio)pyrimidine-4,6-diamine

Base Information

Chemical Name:2-(((2-(3-(2-fluoroethoxy)-4-methoxyphenyl)-5-methylthiazol-4-yl)methyl)thio)pyrimidine-4,6-diamine
CAS No.:1398229-59-8
Molecular Formula:C₁₈H₂₀FN₅O₂S₂
Molecular Weight:421.52
Hs Code.:

Synonyms:2-(((2-(3-(2-fluoroethoxy)-4-methoxyphenyl)-5-methylthiazol-4-yl)methyl)thio)pyrimidine-4,6-diamine

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Chemical Property of 2-(((2-(3-(2-fluoroethoxy)-4-methoxyphenyl)-5-methylthiazol-4-yl)methyl)thio)pyrimidine-4,6-diamine

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Technology Process of 2-(((2-(3-(2-fluoroethoxy)-4-methoxyphenyl)-5-methylthiazol-4-yl)methyl)thio)pyrimidine-4,6-diamine

There total 7 articles about 2-(((2-(3-(2-fluoroethoxy)-4-methoxyphenyl)-5-methylthiazol-4-yl)methyl)thio)pyrimidine-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1004-39-3
4,6-diaminopyrimidine-2(1H)-thione

: 1398230-14-2
4-(bromomethyl)-2-(3-(2-fluoroethoxy)-4-methoxyphenyl)-5-methylthiazole

: 1398229-59-8
2-(((2-(3-(2-fluoroethoxy)-4-methoxyphenyl)-5-methylthiazol-4-yl)methyl)thio)pyrimidine-4,6-diamine

Guidance literature:: 4,6-diaminopyrimidine-2(1H)-thione; With sodium hydroxide; In ethanol; at 20 ℃; for 0.166667h;

4-(bromomethyl)-2-(3-(2-fluoroethoxy)-4-methoxyphenyl)-5-methylthiazole; In ethanol; at 70 ℃; for 3h;

Reference yield: 71.0%

: 1398230-14-2
4-(bromomethyl)-2-(3-(2-fluoroethoxy)-4-methoxyphenyl)-5-methylthiazole

: 1004-39-3
4,6-diamino-2-mercaptopyrimidine

: 1398229-59-8
2-(((2-(3-(2-fluoroethoxy)-4-methoxyphenyl)-5-methylthiazol-4-yl)methyl)thio)pyrimidine-4,6-diamine

Guidance literature:: 4,6-diamino-2-mercaptopyrimidine; With sodium hydroxide; In ethanol; at 23 ℃; for 0.166667h; Inert atmosphere;

4-(bromomethyl)-2-(3-(2-fluoroethoxy)-4-methoxyphenyl)-5-methylthiazole; In ethanol; at 70 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm400457y

Reference yield:

: 1398229-90-7
3-(2-fluoroethoxy)-4-methoxybenzothioamide

: 1398229-59-8
2-(((2-(3-(2-fluoroethoxy)-4-methoxyphenyl)-5-methylthiazol-4-yl)methyl)thio)pyrimidine-4,6-diamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 2.5 h / Reflux; Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 55 °C / Inert atmosphere

2.2: 0 °C

3.1: triphenylphosphine; hexabromoacetone / acetonitrile / 1 h / 0 - 40 °C / Inert atmosphere

4.1: sodium hydroxide / ethanol / 0.17 h / 20 °C

4.2: 3 h / 70 °C

With lithium aluminium tetrahydride; hexabromoacetone; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; ethanol; acetonitrile;