1004-39-3Relevant articles and documents
Design, synthesis, and biological evaluation of 4-aminopyrimidine or 4,6-diaminopyrimidine derivatives as beta amyloid cleaving enzyme-1 inhibitors
Xu, Xiufeng,Peng,Wang, Junjie,Xu, Fengrong,Liang, Lei,Wang, Chao,Niu, Yan,Xu, Ping
, p. 926 - 933 (2019)
A series of novel aminopyrimidine and diaminopyrimidine derivatives were designed and optimized to improve their potency and permeability relative to lead compound 1 (IC50?=?37.4?μM), which was discovered in a previous virtual screening. The po
2-[(3,3,3-trifluoropropyl)thio]-6-amino-9H-purine and preparation method thereof
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Paragraph 0113-0114; 0119; 0122; 0123-0125; 0128, (2018/05/16)
The invention discloses 2-[(3,3,3-trifluoropropyl)thio]-6-amino-9H-purine and a preparation method thereof. 2-[(3,3,3-trifluoropropyl)thio]-6-amino-9H-purine can be used for preparation of 6-N-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]adenosine
Method for synthesis of adenine (by machine translation)
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Paragraph 0034; 0086; 0106, (2017/02/24)
The invention discloses a synthetic method for adenine. Malononitrile and thiourea are employed as raw materials. The raw materials are subjected to a cyclization reaction under action of sodium alkoxide, and 4,6-diamino-2-sulfydryl pyrimidine. Then through three reaction routes, adenine is obtained. Though the method has many reaction steps, no refining or drying are needed for the product of each reaction step, the product can be used in the next reaction step, and the operation is simple. The raw materials are easily available, the prices are relatively low, the reaction conditions are mild, the operation is simple, the reaction steps are decreased, the reaction time is shortened, the overall reaction yield is high, and the synthetic method is suitable for industrial production.