N-((1R,2R)-2-amino-1,2-diphenylethyl)-4-methoxybenzenesulfonamide

Base Information

• Chemical Name: N-((1R,2R)-2-amino-1,2-diphenylethyl)-4-methoxybenzenesulfonamide
• CAS No.: 511534-43-3
• Molecular Formula: C₂₁H₂₂N₂O₃S
• Molecular Weight: 382.483
• Mol file: 511534-43-3.mol

Synonyms:N-((1R,2R)-2-amino-1,2-diphenylethyl)-4-methoxybenzenesulfonamide

Chemical Property of N-((1R,2R)-2-amino-1,2-diphenylethyl)-4-methoxybenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of N-((1R,2R)-2-amino-1,2-diphenylethyl)-4-methoxybenzenesulfonamide

There total 1 articles about N-((1R,2R)-2-amino-1,2-diphenylethyl)-4-methoxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

(R,R)-1,2-diphenylethylenediamine (35132-20-8) + 4-methoxy-phenyl-sulphonyl chloride (98-68-0) → N-((1R,2R)-2-amino-1,2-diphenylethyl)-4-methoxybenzenesulfonamide (511534-43-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h;

DOI:10.1021/jacs.9b00535 DOI:10.1021/jacs.9b00535

Reference yield: 90.0%

N-((1R,2R)-2-amino-1,2-diphenylethyl)-4-methoxybenzenesulfonamide (511534-43-3) + 2-hydroxy-5-methyl-3-(piperidin-1-ylmethyl)-benzaldehyde (165672-87-7) → C35H41N3O4S

Guidance literature:

N-((1R,2R)-2-amino-1,2-diphenylethyl)-4-methoxybenzenesulfonamide; 2-hydroxy-5-methyl-3-(piperidin-1-ylmethyl)-benzaldehyde; In ethanol; at 20 ℃;

With sodium tetrahydroborate; ethanol; at 0 - 20 ℃;

DOI:10.1021/acs.orglett.1c01896

Reference yield: 89.0%

2,6-Pyridinedicarboxaldehyde (5431-44-7) + N-((1R,2R)-2-amino-1,2-diphenylethyl)-4-methoxybenzenesulfonamide (511534-43-3) → 2-((4R,5R)-1-((4-methoxyphenyl)sulfonyl)-4,5-diphenylimidazolidin-2-yl)-6-((4R,5R)-1-((4-methoxyphenyl)sulfonyl)-4,5-diphenylimidazolidin-2-yl)pyridine

Guidance literature:

With acetic acid; In dichloromethane; at 30 ℃; Inert atmosphere;

DOI:10.1021/ja502167h

upstream raw materials:

(R,R)-1,2-diphenylethylenediamine

4-methoxy-phenyl-sulphonyl chloride

Downstream raw materials:

{Cp*Ir[(R,R)-p-OMe-C₆H₄-DPEN](H₂O)}(SO₄)