Technology Process of 3,5-dichloro-4-(4-chloro-thiazolo[5,4-c]pyridine-2-yl)-benzonitrile
There total 6 articles about 3,5-dichloro-4-(4-chloro-thiazolo[5,4-c]pyridine-2-yl)-benzonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,6-dichloro-N-(2-chloro-3-fluoro-pyridin-4-yl)-4-cyano-benzimidoyl chloride;
With
pyridine; thiourea;
In
isopropyl alcohol;
for 16h;
Inert atmosphere;
Reflux;
With
triethylamine;
In
isopropyl alcohol;
for 6.5h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: diphenyl phosphoryl azide / toluene / 3 h / 110 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C
2.2: NH2 cartridge
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h
3.2: 18 h
4.1: thionyl chloride / 18 h / Reflux
5.1: thiourea; pyridine / isopropyl alcohol / 16 h / Inert atmosphere; Reflux
5.2: 6.5 h / Reflux
With
pyridine; thionyl chloride; diphenyl phosphoryl azide; sodium hydride; thiourea; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; isopropyl alcohol; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h
1.2: 18 h
2.1: thionyl chloride / 18 h / Reflux
3.1: thiourea; pyridine / isopropyl alcohol / 16 h / Inert atmosphere; Reflux
3.2: 6.5 h / Reflux
With
pyridine; thionyl chloride; sodium hydride; thiourea;
In
tetrahydrofuran; isopropyl alcohol; mineral oil;
