(1S,2R)-1-(4-Isopropyl-phenyl)-cyclopropane-1,2-dicarboxylic acid diethyl ester

Base Information

Chemical Name:(1S,2R)-1-(4-Isopropyl-phenyl)-cyclopropane-1,2-dicarboxylic acid diethyl ester
CAS No.:77053-73-7
Molecular Formula:C₁₈H₂₄O₄
Molecular Weight:304.386
Hs Code.:

Synonyms:(1S,2R)-1-(4-Isopropyl-phenyl)-cyclopropane-1,2-dicarboxylic acid diethyl ester

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Chemical Property of (1S,2R)-1-(4-Isopropyl-phenyl)-cyclopropane-1,2-dicarboxylic acid diethyl ester

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Technology Process of (1S,2R)-1-(4-Isopropyl-phenyl)-cyclopropane-1,2-dicarboxylic acid diethyl ester

There total 4 articles about (1S,2R)-1-(4-Isopropyl-phenyl)-cyclopropane-1,2-dicarboxylic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 77053-59-9
Brom-(4-isopropyl-phenyl)-essigsaeure-ethylester

: 140-88-5,9003-32-1
ethyl acrylate

: 77053-73-7
(1S,2R)-1-(4-Isopropyl-phenyl)-cyclopropane-1,2-dicarboxylic acid diethyl ester

Guidance literature:: With sodium ethanolate; In diethyl ether; for 24h; Ambient temperature;
DOI:10.1021/jm00137a002

Reference yield:

: 98-82-8
Isopropylbenzene

: 77053-73-7
(1S,2R)-1-(4-Isopropyl-phenyl)-cyclopropane-1,2-dicarboxylic acid diethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 60 percent / AlCl₃ / nitrobenzene

2: 94 percent / H₂ / 10percent Pd/C / ethanol

3: 92 percent / PBr₃ / CHCl₃

4: 73 percent / NaOEt / diethyl ether / 24 h / Ambient temperature

With aluminium trichloride; hydrogen; sodium ethanolate; phosphorus tribromide; palladium on activated charcoal; In diethyl ether; ethanol; chloroform; nitrobenzene;
DOI:10.1021/jm00137a002

Reference yield:

: 34906-84-8
ethyl 2-(4-isopropylphenyl)-2-oxoacetate

: 77053-73-7
(1S,2R)-1-(4-Isopropyl-phenyl)-cyclopropane-1,2-dicarboxylic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / H₂ / 10percent Pd/C / ethanol

2: 92 percent / PBr₃ / CHCl₃

3: 73 percent / NaOEt / diethyl ether / 24 h / Ambient temperature

With hydrogen; sodium ethanolate; phosphorus tribromide; palladium on activated charcoal; In diethyl ether; ethanol; chloroform;
DOI:10.1021/jm00137a002