methyl 2,3-dihydro-3-phenylbenzo[b][1,4]dioxine-2-carboxylate

Base Information

• Chemical Name: methyl 2,3-dihydro-3-phenylbenzo[b][1,4]dioxine-2-carboxylate
• CAS No.: 21770-49-0
• Molecular Formula: C₁₆H₁₄O₄
• Molecular Weight: 270.285
• Mol file: 21770-49-0.mol

Synonyms:methyl 2,3-dihydro-3-phenylbenzo[b][1,4]dioxine-2-carboxylate

Chemical Property of methyl 2,3-dihydro-3-phenylbenzo[b][1,4]dioxine-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2,3-dihydro-3-phenylbenzo[b][1,4]dioxine-2-carboxylate

There total 2 articles about methyl 2,3-dihydro-3-phenylbenzo[b][1,4]dioxine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2,3-dibromo-3-phenylpropanoate (21770-48-9,52742-03-7,52777-73-8,113569-01-0,113626-43-0) + benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) → methyl 2,3-dihydro-3-phenylbenzo[b][1,4]dioxine-2-carboxylate (21770-49-0)

Guidance literature:

benzene-1,2-diol; With potassium carbonate; In acetone; for 0.25h; Reflux; Heating;

methyl 2,3-dibromo-3-phenylpropanoate; With potassium carbonate; In acetone; for 1h; Reflux;

DOI:10.1016/j.bmcl.2014.02.031

Reference yield:

methyl cinnamate (103-26-4,1754-62-7) → methyl 2,3-dihydro-3-phenylbenzo[b][1,4]dioxine-2-carboxylate (21770-49-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: bromine / dichloromethane / 20 °C

2.1: potassium carbonate / acetone / 0.25 h / Reflux; Heating

2.2: 1 h / Reflux

With bromine; potassium carbonate; In dichloromethane; acetone;

DOI:10.1016/j.bmcl.2014.02.031

Reference yield:

methyl 2,3-dihydro-3-phenylbenzo[b][1,4]dioxine-2-carboxylate (21770-49-0) → (2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methanol (24127-63-7)

Guidance literature:

With sodium tetrahydroborate; titanium tetrachloride; In 1,2-dimethoxyethane; at 0 - 20 ℃;

DOI:10.1002/ardp.201300238

upstream raw materials:

methyl cinnamate

methyl 2,3-dibromo-3-phenylpropanoate

benzene-1,2-diol

Downstream raw materials:

3-(1-phenylmethylidene)-1,4-benzodioxin-2-one

2-(2-hydroxyphenoxy)-3-phenyl-2-propenoic acid

methyl 2-<2-(2-diethylaminoethoxy)phenoxy>-3-phenyl-2-propenoate

2-diethylaminoethyl 2-<2-(2-diethylaminoethoxy)phenoxy>-3-phenyl-2-propenoate