ethyl 2-((6-amino-2-butoxy-5-nitropyrimidin-4-yl)(3-cyanobenzyl)amino)acetate

Base Information

Chemical Name:ethyl 2-((6-amino-2-butoxy-5-nitropyrimidin-4-yl)(3-cyanobenzyl)amino)acetate
CAS No.:1228588-12-2
Molecular Formula:C₂₀H₂₄N₆O₅
Molecular Weight:428.448
Hs Code.:

Synonyms:ethyl 2-((6-amino-2-butoxy-5-nitropyrimidin-4-yl)(3-cyanobenzyl)amino)acetate

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Chemical Property of ethyl 2-((6-amino-2-butoxy-5-nitropyrimidin-4-yl)(3-cyanobenzyl)amino)acetate

Chemical Property:

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Technology Process of ethyl 2-((6-amino-2-butoxy-5-nitropyrimidin-4-yl)(3-cyanobenzyl)amino)acetate

There total 3 articles about ethyl 2-((6-amino-2-butoxy-5-nitropyrimidin-4-yl)(3-cyanobenzyl)amino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₁₈N₆O₆S

: 71-36-3
butan-1-ol

: 1228588-12-2
ethyl 2-((6-amino-2-butoxy-5-nitropyrimidin-4-yl)(3-cyanobenzyl)amino)acetate

Guidance literature:: With trifluoroacetic acid; at 100 ℃;

Reference yield:

: ((2-ethoxy-2-oxoethylamino)methyl)benzonitrile

: 1228588-12-2
ethyl 2-((6-amino-2-butoxy-5-nitropyrimidin-4-yl)(3-cyanobenzyl)amino)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / tetrahydrofuran; methanol / 1 h / 0 °C / Inert atmosphere

1.2: 16 h / 20 °C / Inert atmosphere

2.1: peracetic acid / acetonitrile / 2 h / Inert atmosphere; Cooling with ice

3.1: trifluoroacetic acid / 100 °C

With peracetic acid; ammonia; trifluoroacetic acid; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/jm400815m

Reference yield:

: 1228588-11-1
ethyl 2-((6-amino-2-(methylthio)-5-nitropyrimidin-4-yl)(3-cyanobenzyl)amino)acetate

: 1228588-12-2
ethyl 2-((6-amino-2-butoxy-5-nitropyrimidin-4-yl)(3-cyanobenzyl)amino)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: peracetic acid / acetonitrile / 2 h / Inert atmosphere; Cooling with ice

2: trifluoroacetic acid / 100 °C

With peracetic acid; trifluoroacetic acid; In acetonitrile;
DOI:10.1021/jm400815m