3-((4-amino-2-butoxy-6-oxo-6,7-dihydropteridin-8(5H)-yl)methyl)benzonitrile

Base Information

Chemical Name:3-((4-amino-2-butoxy-6-oxo-6,7-dihydropteridin-8(5H)-yl)methyl)benzonitrile
CAS No.:1228585-84-9
Molecular Formula:C₁₈H₂₀N₆O₂
Molecular Weight:352.396
Hs Code.:

Synonyms:3-((4-amino-2-butoxy-6-oxo-6,7-dihydropteridin-8(5H)-yl)methyl)benzonitrile

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Chemical Property of 3-((4-amino-2-butoxy-6-oxo-6,7-dihydropteridin-8(5H)-yl)methyl)benzonitrile

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Technology Process of 3-((4-amino-2-butoxy-6-oxo-6,7-dihydropteridin-8(5H)-yl)methyl)benzonitrile

There total 4 articles about 3-((4-amino-2-butoxy-6-oxo-6,7-dihydropteridin-8(5H)-yl)methyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1228588-12-2
ethyl 2-((6-amino-2-butoxy-5-nitropyrimidin-4-yl)(3-cyanobenzyl)amino)acetate

: 1228585-84-9
3-((4-amino-2-butoxy-6-oxo-6,7-dihydropteridin-8(5H)-yl)methyl)benzonitrile

Guidance literature:: ethyl 2-((6-amino-2-butoxy-5-nitropyrimidin-4-yl)(3-cyanobenzyl)amino)acetate; With hydrogen; palladium 10% on activated carbon; In ethanol; acetonitrile; for 18h;

With hydrogenchloride; In ethanol; water; acetonitrile;

Reference yield:

: ((2-ethoxy-2-oxoethylamino)methyl)benzonitrile

: 1228585-84-9
3-((4-amino-2-butoxy-6-oxo-6,7-dihydropteridin-8(5H)-yl)methyl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonia / tetrahydrofuran; methanol / 1 h / 0 °C / Inert atmosphere

1.2: 16 h / 20 °C / Inert atmosphere

2.1: peracetic acid / acetonitrile / 2 h / Inert atmosphere; Cooling with ice

3.1: trifluoroacetic acid / 100 °C

4.1: hydrogen; palladium on activated charcoal / ethanol; acetonitrile / 18 h

With peracetic acid; palladium on activated charcoal; ammonia; hydrogen; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; acetonitrile;
DOI:10.1021/jm400815m

Reference yield:

: C₁₇H₁₈N₆O₆S

: 1228585-84-9
3-((4-amino-2-butoxy-6-oxo-6,7-dihydropteridin-8(5H)-yl)methyl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / 100 °C

2: hydrogen; palladium on activated charcoal / ethanol; acetonitrile / 18 h

With palladium on activated charcoal; hydrogen; trifluoroacetic acid; In ethanol; acetonitrile;
DOI:10.1021/jm400815m