rac-2-cyano-N-(1-methyl-3-phenyl-piperidin-3-yl)-4-trifluoromethyl-benzamide

Base Information

Chemical Name:rac-2-cyano-N-(1-methyl-3-phenyl-piperidin-3-yl)-4-trifluoromethyl-benzamide
CAS No.:1558680-98-0
Molecular Formula:C₂₁H₂₀F₃N₃O
Molecular Weight:387.405
Hs Code.:

Synonyms:rac-2-cyano-N-(1-methyl-3-phenyl-piperidin-3-yl)-4-trifluoromethyl-benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of rac-2-cyano-N-(1-methyl-3-phenyl-piperidin-3-yl)-4-trifluoromethyl-benzamide

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Technology Process of rac-2-cyano-N-(1-methyl-3-phenyl-piperidin-3-yl)-4-trifluoromethyl-benzamide

There total 5 articles about rac-2-cyano-N-(1-methyl-3-phenyl-piperidin-3-yl)-4-trifluoromethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1236302-33-2
rac-1-methyl-3-phenyl-piperidin-3-ylamine

: 779-16-8
4-Trifluormethyl-2-cyan-benzoesaeure

: 1558680-98-0
rac-2-cyano-N-(1-methyl-3-phenyl-piperidin-3-yl)-4-trifluoromethyl-benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 20h;
DOI:10.1021/ml500005m

Reference yield:

: 1236302-32-1
rac-3-azido-3-phenyl-piperidine-1-carboxylic acid benzyl ester

: 1558680-98-0
rac-2-cyano-N-(1-methyl-3-phenyl-piperidin-3-yl)-4-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 10 - 65 °C

2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 h / 20 °C

With lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ml500005m

Reference yield:

: 61995-20-8
N-(benzyloxycarbonyl)-3-piperidone

: 1558680-98-0
rac-2-cyano-N-(1-methyl-3-phenyl-piperidin-3-yl)-4-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 0.75 h / 20 °C

2: sodium azide / water; trifluoroacetic acid / 3 h / 0 - 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 10 - 65 °C

4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 h / 20 °C

With lithium aluminium tetrahydride; sodium azide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; water; N,N-dimethyl-formamide; trifluoroacetic acid;
DOI:10.1021/ml500005m