1236302-33-2

Upstream product

• 1236302-31-0 rac-3-hydroxy-3-phenyl-piperidine-1-carboxylic acid benzyl ester 
• 100-58-3 phenylmagnesium bromide 
• 61995-20-8 N-(benzyloxycarbonyl)-3-piperidone 
• 1236302-32-1 rac-3-azido-3-phenyl-piperidine-1-carboxylic acid benzyl ester 

Downstream Products

• 1236303-48-2 rac-2-Chloro-N-(1-methyl-3-phenyl-piperidin-3-yl)-3-trifluoromethyl-benzamide 
• 1236301-58-8 rac-2-methoxy-N-(1-methyl-3-phenyl-piperidin-3-yl)-4,6-bis-trifluoromethyl-benzamide 
• 1236301-71-5 (R)-2-methoxy-N-(1-methyl-3-phenyl-piperidin-3-yl)-6-methylsulfanyl-4-trifluoromethyl benzamide 
• 1236301-70-4 (S)-2-methoxy-N-(1-methyl-3-phenyl-piperidin-3-yl)-6-methylsulfanyl-4-trifluoromethylbenzamide 
• 1558680-93-5 rac-2-methoxy-N-(1-methyl-3-phenyl-piperidin-3-yl)-4-trifluoromethyl-benzamide 
• 1558680-96-8 rac-N-(1-methyl-3-phenyl-piperidin-3-yl)-4-trifluoromethyl-benzamide 
• 1558680-98-0 rac-2-cyano-N-(1-methyl-3-phenyl-piperidin-3-yl)-4-trifluoromethyl-benzamide 
• 1558681-00-7 rac-2-fluoro-N-(1-methyl-3-phenyl-piperidin-3-yl)-4-trifluoromethyl-benzamide 
• 1236303-67-5 rac-2-methyl-N-(1-methyl-3-phenyl-piperidin-3-yl)-4-trifluoromethyl-benzamide 
• 1236303-54-0 rac-2-bromo-N-(1-methyl-3-phenyl-piperidin-3-yl)-4-trifluoromethyl-benzamide 
• 1236301-67-9 rac-N-(1-methyl-3-phenyl-piperidin-3-yl)-2-methylsulfanyl-4-trifluoromethyl-benzamide 
• 1236301-66-8 rac-2-methoxy-N-(1-methyl-3-phenyl-piperidin-3-yl)-6-methylsulfanyl-4-trifluoromethylbenzamide 
• 1236303-66-4 rac-2,4-dichloro-N-(1-methyl-3-phenyl-piperidin-3-yl)-benzamide 
• 1558680-91-3 rac-2-methoxy-N-(1-methyl-3-phenyl-piperidin-3-yl)-6-trifluoromethyl-benzamide 

Relevant academic research and scientific papers

3-amido-3-aryl-piperidines: A novel class of potent, selective, and orally active GlyT1 inhibitors

3-Amido-3-aryl-piperidines were discovered as a novel structural class of GlyT1 inhibitors. The structure-activity relationship, which was developed, led to the identification of highly potent compounds exhibiting excellent selectivity against the GlyT2 isoform, drug-like properties, and in vivo activity after oral administration.

PIPERIDINE DERIVATIVES

The present invention relates to a compound of formula I wherein R1, R2, and Ar are as defined herein or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical iso